A clinical SARS-CoV-2 M^pro inhibitor blocks replication of multiple enteroviruses and confers oral in vivo protection in animal models

• Zhengyu Ye ,

  Contributed equally to this work with: Zhengyu Ye, Wenhao Dai, Shaolin Zhang, Yingchun Xiang

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft

  Affiliations State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China, University of the Chinese Academy of Sciences, Beijing China

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• Wenhao Dai ,

  Contributed equally to this work with: Zhengyu Ye, Wenhao Dai, Shaolin Zhang, Yingchun Xiang

  Roles Investigation

  Affiliations State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China, School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, China

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• Shaolin Zhang ,

  Contributed equally to this work with: Zhengyu Ye, Wenhao Dai, Shaolin Zhang, Yingchun Xiang

  Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

  Affiliations HuaWu Biotech, Wuhan, China, Hubei Jiangxia Laboratory, Wuhan, China

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• Yingchun Xiang ,

  Contributed equally to this work with: Zhengyu Ye, Wenhao Dai, Shaolin Zhang, Yingchun Xiang

  Roles Investigation

  Affiliations HuaWu Biotech, Wuhan, China, Hubei Jiangxia Laboratory, Wuhan, China

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• Jinlin Wang,

  Roles Investigation

  Affiliation State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

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• Yumin Zhang,

  Roles Investigation

  Affiliations State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China, University of the Chinese Academy of Sciences, Beijing China

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• Wenyuan Cao,

  Roles Investigation

  Affiliations HuaWu Biotech, Wuhan, China, Hubei Jiangxia Laboratory, Wuhan, China

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• Johan Neyts,

  Roles Writing – review & editing

  Affiliation University of Leuven, Leuven, Belgium

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• Zuyi Li,

  Roles Investigation

  Affiliation Huazhong University of Science and Technology, Wuhan China

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• Fan Feng,

  Roles Investigation

  Affiliations State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China, School of Chemical Engineering and Pharmacy, and Hubei Key Laboratory of Novel Reactor and Green Chemical Technology, Wuhan Institute of Technology, Wuhan China

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• Gengfu Xiao,

  Roles Funding acquisition, Writing – review & editing

  Affiliations State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China, University of the Chinese Academy of Sciences, Beijing China

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• Hong Liu ,

  Roles Conceptualization, Funding acquisition, Writing – review & editing

  * E-mail: hliu@simm.ac.cn (HL); caojunyuan@wh.iov.cn (JC); zhangleike@wh.iov.cn (LZ)

  Affiliations State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China, School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, China

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• Junyuan Cao ,

  Roles Conceptualization, Formal analysis, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft

  * E-mail: hliu@simm.ac.cn (HL); caojunyuan@wh.iov.cn (JC); zhangleike@wh.iov.cn (LZ)

  Affiliations State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China, University of the Chinese Academy of Sciences, Beijing China

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• Lei-ke Zhang

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Validation, Writing – review & editing

  * E-mail: hliu@simm.ac.cn (HL); caojunyuan@wh.iov.cn (JC); zhangleike@wh.iov.cn (LZ)

  Affiliations State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China, University of the Chinese Academy of Sciences, Beijing China, Hubei Jiangxia Laboratory, Wuhan, China

  https://orcid.org/0000-0002-2593-2571

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