Schistosome esophageal gland factor MEG-8.2 drives host cell lysis and interacts with host immune proteins

Pallavi Yadav; Sabona B. Simbassa; Ryan Sloan; Phillip A. Newmark; Jayhun Lee

doi:10.1371/journal.ppat.1014044

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Peer-reviewed

Research Article

Schistosome esophageal gland factor MEG-8.2 drives host cell lysis and interacts with host immune proteins

Pallavi Yadav,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Microbiology and Molecular Genetics, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America
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Sabona B. Simbassa,

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Microbiology and Infectious Diseases Program, The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, Houston, Texas, United States of America
⨯
Ryan Sloan,

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Microbiology and Infectious Diseases Program, The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, Houston, Texas, United States of America
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Phillip A. Newmark,

Roles Funding acquisition, Supervision, Writing – review & editing

Affiliation Howard Hughes Medical Institute, Morgridge Institute for Research, Department of Integrative Biology, University of Wisconsin–Madison, Madison, Wisconsin, United States of America
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Jayhun Lee

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: Jayhun.Lee@uth.tmc.edu

Affiliations Department of Microbiology and Molecular Genetics, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America, Microbiology and Infectious Diseases Program, The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, Houston, Texas, United States of America

https://orcid.org/0000-0003-3967-3424

⨯

Schistosome esophageal gland factor MEG-8.2 drives host cell lysis and interacts with host immune proteins

Pallavi Yadav,
Sabona B. Simbassa,
Ryan Sloan,
Phillip A. Newmark,
Jayhun Lee

Published: March 11, 2026
https://doi.org/10.1371/journal.ppat.1014044
See the preprint

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Schistosoma
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