PDE4B deficiency aids macrophage differentiation and contributes to Cryptococcus neoformans brain infection

Ying Gong; Ting Wang; Xin Chen; Yuwei Li; Shaofan Ye; Shan Liu; Chunan Sun; Xia Zhang; Chen Yang; Yonglin Yang; Guannan Zhang; Mingshun Zhang

doi:10.1371/journal.ppat.1014040

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Open Access

Peer-reviewed

Research Article

PDE4B deficiency aids macrophage differentiation and contributes to Cryptococcus neoformans brain infection

Ying Gong ,

Contributed equally to this work with: Ying Gong, Ting Wang, Xin Chen

Roles Data curation, Formal analysis, Investigation, Software, Validation, Visualization, Writing – original draft

Affiliations Department of Immunology, National Vaccine Innovation Platform, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, China, NHC Key Laboratory of Antibody Technique, Jiangsu Key Laboratory of Pathogen Biology, Department of Immunology, Nanjing Medical University, Nanjing, China
⨯
Ting Wang ,

Contributed equally to this work with: Ying Gong, Ting Wang, Xin Chen

Roles Data curation, Formal analysis, Investigation, Software, Validation, Visualization

Affiliations Department of Immunology, National Vaccine Innovation Platform, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, China, NHC Key Laboratory of Antibody Technique, Jiangsu Key Laboratory of Pathogen Biology, Department of Immunology, Nanjing Medical University, Nanjing, China
⨯
Xin Chen ,

Contributed equally to this work with: Ying Gong, Ting Wang, Xin Chen

Roles Formal analysis, Investigation, Validation, Visualization

Affiliations Department of Immunology, National Vaccine Innovation Platform, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, China, NHC Key Laboratory of Antibody Technique, Jiangsu Key Laboratory of Pathogen Biology, Department of Immunology, Nanjing Medical University, Nanjing, China
⨯
Yuwei Li,

Roles Formal analysis, Investigation

Affiliations Department of Immunology, National Vaccine Innovation Platform, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, China, NHC Key Laboratory of Antibody Technique, Jiangsu Key Laboratory of Pathogen Biology, Department of Immunology, Nanjing Medical University, Nanjing, China
⨯
Shaofan Ye,

Roles Methodology

Affiliations Department of Immunology, National Vaccine Innovation Platform, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, China, NHC Key Laboratory of Antibody Technique, Jiangsu Key Laboratory of Pathogen Biology, Department of Immunology, Nanjing Medical University, Nanjing, China
⨯
Shan Liu,

Roles Methodology

Affiliations Department of Immunology, National Vaccine Innovation Platform, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, China, NHC Key Laboratory of Antibody Technique, Jiangsu Key Laboratory of Pathogen Biology, Department of Immunology, Nanjing Medical University, Nanjing, China
⨯
Chunan Sun,

Roles Methodology

Affiliations Department of Immunology, National Vaccine Innovation Platform, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, China, NHC Key Laboratory of Antibody Technique, Jiangsu Key Laboratory of Pathogen Biology, Department of Immunology, Nanjing Medical University, Nanjing, China
⨯
Xia Zhang,

Roles Methodology

Affiliation Department of Infectious Diseases, The Affiliated Taizhou People’s Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Nanjing, China
⨯
Chen Yang,

Roles Methodology

Affiliations Department of Immunology, National Vaccine Innovation Platform, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, China, NHC Key Laboratory of Antibody Technique, Jiangsu Key Laboratory of Pathogen Biology, Department of Immunology, Nanjing Medical University, Nanjing, China
⨯
Yonglin Yang ,

Roles Conceptualization, Project administration, Resources, Writing – review & editing

* E-mail: mingshunzhang@njmu.edu.cn (MZ); easing@163.com (YY); gnzhang@njmu.edu.cn (GZ)

Affiliation Department of Infectious Diseases, The Affiliated Taizhou People’s Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Nanjing, China
⨯
Guannan Zhang ,

Roles Data curation, Formal analysis, Investigation, Writing – original draft

* E-mail: mingshunzhang@njmu.edu.cn (MZ); easing@163.com (YY); gnzhang@njmu.edu.cn (GZ)

Affiliation Department of Immunology, National Vaccine Innovation Platform, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, China
⨯
Mingshun Zhang

Roles Conceptualization, Project administration, Resources, Supervision, Writing – review & editing

* E-mail: mingshunzhang@njmu.edu.cn (MZ); easing@163.com (YY); gnzhang@njmu.edu.cn (GZ)

Affiliations Department of Immunology, National Vaccine Innovation Platform, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, China, NHC Key Laboratory of Antibody Technique, Jiangsu Key Laboratory of Pathogen Biology, Department of Immunology, Nanjing Medical University, Nanjing, China

https://orcid.org/0000-0001-5925-0168

⨯

PDE4B deficiency aids macrophage differentiation and contributes to Cryptococcus neoformans brain infection

Ying Gong,
Ting Wang,
Xin Chen,
Yuwei Li,
Shaofan Ye,
Shan Liu,
Chunan Sun,
Xia Zhang,
Chen Yang,
Yonglin Yang

Published: March 10, 2026
https://doi.org/10.1371/journal.ppat.1014040

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