The CD97-PPM1G axis dampens antiviral immunity by dephosphorylating IRF7 in type I interferon pathway

Huasong Chang; Wenjing Qi; Rukun Yang; Peili Hou; Ran Kang; Xiaoyu Liu; Yingying Li; Hongmei Wang; Hongbin He

doi:10.1371/journal.ppat.1014032

Loading metrics

Open Access

Peer-reviewed

Research Article

The CD97-PPM1G axis dampens antiviral immunity by dephosphorylating IRF7 in type I interferon pathway

Huasong Chang ,

Contributed equally to this work with: Huasong Chang, Wenjing Qi

Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Visualization, Writing – original draft

Affiliation Ruminant Diseases Research Center, College of Life Sciences, Shandong Normal University, Jinan, Shandong, China

https://orcid.org/0000-0001-6658-828X

⨯
Wenjing Qi ,

Contributed equally to this work with: Huasong Chang, Wenjing Qi

Roles Formal analysis, Investigation, Methodology, Validation, Visualization, Data curation

Affiliation Ruminant Diseases Research Center, College of Life Sciences, Shandong Normal University, Jinan, Shandong, China
⨯
Rukun Yang,

Roles Investigation

Affiliation Ruminant Diseases Research Center, College of Life Sciences, Shandong Normal University, Jinan, Shandong, China
⨯
Peili Hou,

Roles Funding acquisition

Affiliation Ruminant Diseases Research Center, College of Life Sciences, Shandong Normal University, Jinan, Shandong, China
⨯
Ran Kang,

Roles Investigation

Affiliation Ruminant Diseases Research Center, College of Life Sciences, Shandong Normal University, Jinan, Shandong, China
⨯
Xiaoyu Liu,

Roles Investigation

Affiliation Ruminant Diseases Research Center, College of Life Sciences, Shandong Normal University, Jinan, Shandong, China
⨯
Yingying Li,

Roles Investigation

Affiliation Ruminant Diseases Research Center, College of Life Sciences, Shandong Normal University, Jinan, Shandong, China
⨯
Hongmei Wang ,

Roles Conceptualization, Funding acquisition, Writing – review & editing

* E-mail: hongmeiwang@sdnu.edu.cn (HW); hongbinhe@sdnu.edu.cn (HH)

Affiliation Ruminant Diseases Research Center, College of Life Sciences, Shandong Normal University, Jinan, Shandong, China
⨯
Hongbin He

Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – review & editing

* E-mail: hongmeiwang@sdnu.edu.cn (HW); hongbinhe@sdnu.edu.cn (HH)

Affiliation Ruminant Diseases Research Center, College of Life Sciences, Shandong Normal University, Jinan, Shandong, China

https://orcid.org/0000-0002-7438-0638

⨯

The CD97-PPM1G axis dampens antiviral immunity by dephosphorylating IRF7 in type I interferon pathway

Huasong Chang,
Wenjing Qi,
Rukun Yang,
Peili Hou,
Ran Kang,
Xiaoyu Liu,
Yingying Li,
Hongmei Wang,
Hongbin He

Published: March 3, 2026
https://doi.org/10.1371/journal.ppat.1014032

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Viral replication
Is the Subject Area "Viral replication" applicable to this article?

Thanks for your feedback.
Phosphorylation
Is the Subject Area "Phosphorylation" applicable to this article?

Thanks for your feedback.
H1N1
Is the Subject Area "H1N1" applicable to this article?

Thanks for your feedback.
Immunoblotting
Is the Subject Area "Immunoblotting" applicable to this article?

Thanks for your feedback.
Viral transmission and infection
Is the Subject Area "Viral transmission and infection" applicable to this article?

Thanks for your feedback.
HeLa cells
Is the Subject Area "HeLa cells" applicable to this article?

Thanks for your feedback.
Transfection
Is the Subject Area "Transfection" applicable to this article?

Thanks for your feedback.
Transcription factors
Is the Subject Area "Transcription factors" applicable to this article?

Thanks for your feedback.