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Open Access
Peer-reviewed
Research Article
Rab9 depletion enhances human adenovirus type 26 transduction efficiency through increased internalization and reduced late endosomal/lysosomal retention
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Isabela Drašković ,
Contributed equally to this work with: Isabela Drašković, Davor Nestić
Roles Conceptualization, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing
Affiliation Laboratory for Cell Biology and Signalling, Division of Molecular Biology, Ruđer Bošković Institute, Zagreb, Croatia
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Davor Nestić ,
Contributed equally to this work with: Isabela Drašković, Davor Nestić
Roles Conceptualization, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing
Current address: Department of Biochemistry, University of Zürich, Zürich, Switzerland
Affiliation Laboratory for Cell Biology and Signalling, Division of Molecular Biology, Ruđer Bošković Institute, Zagreb, Croatia
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Lucija Lulić Horvat,
Roles Formal analysis, Investigation, Methodology, Visualization
Affiliation Laboratory for Cell Biology and Signalling, Division of Molecular Biology, Ruđer Bošković Institute, Zagreb, Croatia
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Jelena Martinčić,
Roles Investigation, Methodology, Visualization, Writing – review & editing
Affiliation Laboratory for Cell Biology and Signalling, Division of Molecular Biology, Ruđer Bošković Institute, Zagreb, Croatia
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Mario Stojanović,
Roles Investigation, Methodology, Writing – review & editing
Affiliation Laboratory for Cell Biology and Signalling, Division of Molecular Biology, Ruđer Bošković Institute, Zagreb, Croatia
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Gabriela N. Condezo,
Roles Formal analysis, Investigation, Methodology, Visualization, Writing – review & editing
Affiliation Department of Macromolecular Structures, Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain
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Klara Kašnar,
Roles Investigation, Methodology
Affiliation Laboratory for Cell Biology and Signalling, Division of Molecular Biology, Ruđer Bošković Institute, Zagreb, Croatia
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Esther González-Almela,
Roles Investigation, Resources
Affiliation Department of Macromolecular Structures, Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain
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Darío Lago,
Roles Investigation, Resources
Affiliation Department of Macromolecular Structures, Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain
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Carmen San Martín,
Roles Methodology, Resources, Writing – review & editing
Affiliation Department of Macromolecular Structures, Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain
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Jerome Custers,
Roles Methodology, Resources
Current address: Vector Bioconsult, Alphen aan den Rijn, The Netherlands
Affiliation Janssen Vaccines and Prevention B.V., Leiden, The Netherlands
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Dragomira Majhen
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Resources, Supervision, Writing – original draft
* E-mail: dmajhen@irb.hr
Affiliation Laboratory for Cell Biology and Signalling, Division of Molecular Biology, Ruđer Bošković Institute, Zagreb, Croatia
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Rab9 depletion enhances human adenovirus type 26 transduction efficiency through increased internalization and reduced late endosomal/lysosomal retention
- Isabela Drašković,
- Davor Nestić,
- Lucija Lulić Horvat,
- Jelena Martinčić,
- Mario Stojanović,
- Gabriela N. Condezo,
- Klara Kašnar,
- Esther González-Almela,
- Darío Lago,
- Carmen San Martín
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- Published: August 10, 2026
- https://doi.org/10.1371/journal.ppat.1014028