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Open Access
Peer-reviewed
Research Article
TRIM29 knockout pigs exhibit enhanced broad-spectrum disease resilience by amplifying type I interferon antiviral defenses
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Xiaohui Yang,
Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing
Affiliation State Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou, China
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Haiwen Zhong,
Roles Formal analysis, Investigation
Affiliation State Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou, China
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Jie Cheng,
Roles Investigation
Affiliation State Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou, China
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Huijie Jiang,
Roles Investigation
Affiliation State Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou, China
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Jiayong Tan,
Roles Investigation
Affiliation State Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou, China
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Cuizhen Wang,
Roles Investigation
Affiliation State Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou, China
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Changxu Song,
Roles Methodology, Resources
Affiliation State Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou, China
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Gengyuan Cai,
Roles Resources
Affiliations State Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou, China, Yunfu Branch Center of Guangdong Laboratory of Lingnan Modern Agricultural Science and Technology, Yunfu, China
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Huaqiang Yang ,
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Project administration, Writing – original draft, Writing – review & editing
* E-mail: yangh@scau.edu.cn (HY); wzf@scau.edu.cn (ZW)
Affiliations State Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou, China, Yunfu Branch Center of Guangdong Laboratory of Lingnan Modern Agricultural Science and Technology, Yunfu, China
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Zhenfang Wu
Roles Formal analysis, Funding acquisition, Project administration, Supervision, Writing – review & editing
* E-mail: yangh@scau.edu.cn (HY); wzf@scau.edu.cn (ZW)
Affiliations State Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou, China, Yunfu Branch Center of Guangdong Laboratory of Lingnan Modern Agricultural Science and Technology, Yunfu, China
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TRIM29 knockout pigs exhibit enhanced broad-spectrum disease resilience by amplifying type I interferon antiviral defenses
- Xiaohui Yang,
- Haiwen Zhong,
- Jie Cheng,
- Huijie Jiang,
- Jiayong Tan,
- Cuizhen Wang,
- Changxu Song,
- Gengyuan Cai,
- Huaqiang Yang,
- Zhenfang Wu
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- Published: March 2, 2026
- https://doi.org/10.1371/journal.ppat.1014023