Repurposing metformin as a dual-function agent to combat E. coli-induced mastitis: Mechanistic insights into biofilm dispersion and AMPK/SIRT1-mediated NF-κB inhibition

• Tianle Xu ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: tl-xu@yzu.edu.cn (TX); yzp@yzu.edu.cn (ZY)

  Affiliations Joint International Research Laboratory of Agriculture and Agri-Product Safety, Ministry of Education of China, Yangzhou University, Yangzhou, China, College of Animal Science and Technology, Yangzhou University, Yangzhou, China

  https://orcid.org/0000-0002-8479-3372

  ⨯
• Wendi Cao,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  Affiliation College of Animal Science and Technology, Yangzhou University, Yangzhou, China

  ⨯
• Shuangyuan Fan,

  Roles Data curation, Formal analysis, Validation

  Affiliation College of Animal Science and Technology, Yangzhou University, Yangzhou, China

  ⨯
• Run Liu,

  Roles Conceptualization, Investigation, Writing – original draft

  Affiliation College of Animal Science and Technology, Yangzhou University, Yangzhou, China

  ⨯
• Hao Zhu,

  Roles Data curation, Investigation

  Affiliation College of Animal Science and Technology, Yangzhou University, Yangzhou, China

  ⨯
• Xubin Lu,

  Roles Formal analysis, Investigation, Methodology, Validation

  Affiliation College of Animal Science and Technology, Yangzhou University, Yangzhou, China

  ⨯
• Zhipeng Zhang,

  Roles Investigation

  Affiliation College of Animal Science and Technology, Yangzhou University, Yangzhou, China

  ⨯
• Xiaojiao He,

  Roles Data curation, Validation

  Affiliation College of Animal Science and Technology, Yangzhou University, Yangzhou, China

  ⨯
• Kai Zhang,

  Roles Funding acquisition, Resources

  Affiliation Key Laboratory for Crop and Animal Integrated Farming of Ministry of Agriculture and Rural Affairs, Animal Husbandry Institute, Jiangsu Academy of Agricultural Sciences, Nanjing, China

  ⨯
• Jie Huang,

  Roles Resources

  Affiliation Huzhou Academy of Agricultural Sciences, Huzhou, China

  ⨯
• Nana Ma,

  Roles Investigation, Resources

  Affiliation College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China

  ⨯
• Guangjun Chang,

  Roles Resources

  Affiliation College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China

  ⨯
• Zhangping Yang

  Roles Conceptualization, Methodology, Supervision

  * E-mail: tl-xu@yzu.edu.cn (TX); yzp@yzu.edu.cn (ZY)

  Affiliations Joint International Research Laboratory of Agriculture and Agri-Product Safety, Ministry of Education of China, Yangzhou University, Yangzhou, China, College of Animal Science and Technology, Yangzhou University, Yangzhou, China

  ⨯