Conserved non-coding RNA motifs influence the neuropathogenicity of Simbuviruses: Molecular dissection in the Schmallenberg virus model

Laura Bonil; Laetitia Wiggers; Hélène Dumont; Marco Caporale; Marie-Cécile Nollevaux; Charles Nicaise; Benoît Muylkens; Damien Coupeau

doi:10.1371/journal.ppat.1014006

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Open Access

Peer-reviewed

Research Article

Conserved non-coding RNA motifs influence the neuropathogenicity of Simbuviruses: Molecular dissection in the Schmallenberg virus model

Laura Bonil ,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

* E-mail: benoit.muylkens@unamur.be

Affiliation Department of Veterinary Medicine, Namur Research Institute for Life Sciences (NARILIS), Integrated Veterinary Research Unit, University of Namur, Namur, Belgium
⨯
Laetitia Wiggers,

Roles Investigation, Methodology

Affiliation Department of Veterinary Medicine, Namur Research Institute for Life Sciences (NARILIS), Integrated Veterinary Research Unit, University of Namur, Namur, Belgium
⨯
Hélène Dumont,

Roles Investigation

Affiliation Department of Veterinary Medicine, Namur Research Institute for Life Sciences (NARILIS), Integrated Veterinary Research Unit, University of Namur, Namur, Belgium
⨯
Marco Caporale,

Roles Investigation, Methodology

Affiliation Bacterial Vaccine and Diagnostics Production, Istituto Zooprofilattico Sperimentale dell’Abruzzo e Molise “G. Caporale”, Teramo, Italy
⨯
Marie-Cécile Nollevaux,

Roles Investigation

Affiliation Department of Pathology, Namur Research Institute for Life Sciences (NARILIS), CHU UCL Namur, Godinne, Belgium
⨯
Charles Nicaise,

Roles Investigation, Supervision, Visualization

Affiliation Department of Medicine, Namur Research Institute for Life Sciences (NARILIS), Laboratory of Cells and Tissues, University of Namur, Namur, Belgium
⨯
Benoît Muylkens ,

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: benoit.muylkens@unamur.be

Affiliation Department of Veterinary Medicine, Namur Research Institute for Life Sciences (NARILIS), Integrated Veterinary Research Unit, University of Namur, Namur, Belgium

https://orcid.org/0000-0001-5616-5099

⨯
Damien Coupeau

Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

Affiliation Department of Veterinary Medicine, Namur Research Institute for Life Sciences (NARILIS), Integrated Veterinary Research Unit, University of Namur, Namur, Belgium
⨯

Conserved non-coding RNA motifs influence the neuropathogenicity of Simbuviruses: Molecular dissection in the Schmallenberg virus model

Laura Bonil,
Laetitia Wiggers,
Hélène Dumont,
Marco Caporale,
Marie-Cécile Nollevaux,
Charles Nicaise,
Benoît Muylkens,
Damien Coupeau

Published: March 10, 2026
https://doi.org/10.1371/journal.ppat.1014006

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Messenger RNA
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Signal termination
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RNA structure
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Nucleotides
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Sequence motif analysis
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