Detection and characterization of Hepatitis B virus double-stranded linear DNA-derived covalently closed circular DNA in chronic hepatitis B patients

• Hsin-Ni Liu,

  Roles Data curation, Formal analysis, Investigation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation The Baruch S. Blumberg Institute, Translational Medical Science, Doylestown, Pennsylvania, United States of America

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• Elena Kim,

  Roles Investigation

  Affiliation Department of Microbiology and Molecular Genetics; Cancer Virology Program, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

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• Ning Sun,

  Roles Investigation

  Affiliation Department of Microbiology and Molecular Genetics; Cancer Virology Program, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

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• Zhili Wang,

  Roles Methodology

  Affiliation JBS Science Inc, Doylestown, Pennsylvania, United States of America

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• ThiThuyTu Nguyen,

  Roles Investigation

  Affiliation The Baruch S. Blumberg Institute, Translational Medical Science, Doylestown, Pennsylvania, United States of America

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• Fwu-Shan Shieh,

  Roles Software

  Affiliation JBS Science Inc, Doylestown, Pennsylvania, United States of America

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• Yuanjie Liu,

  Roles Investigation

  Affiliation Department of Microbiology and Molecular Genetics; Cancer Virology Program, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

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• Marc G. Ghany,

  Roles Resources

  Affiliation National Institutes of Health, Liver Diseases Branch, NIDDK, Bethesda, Maryland, United States of America

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• Raymond T. Chung,

  Roles Resources

  Affiliation Massachusetts General Hospital, Harvard Medical School, Liver Center, GI Division, Boston, Massachusetts, United States of America

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• Richard K. Sterling,

  Roles Resources

  Affiliation Virginia Commonwealth University, Gastroenterology and Hepatology, Richmond, Virginia, United States of America

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• Selena Y. Lin,

  Roles Funding acquisition, Methodology

  Affiliation JBS Science Inc, Doylestown, Pennsylvania, United States of America

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• Haitao Guo ,

  Roles Conceptualization, Funding acquisition, Methodology, Resources, Writing – review & editing

  * E-mail: Ying-hsiu.su@bblumberg.org (Y-HS); guoh4@upmc.edu (HG); dlau@bidmc.harvard.edu (DTYL)

  Affiliation Department of Microbiology and Molecular Genetics; Cancer Virology Program, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

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• Daryl T. Y. Lau ,

  Roles Conceptualization, Funding acquisition, Methodology, Resources, Writing – review & editing

  * E-mail: Ying-hsiu.su@bblumberg.org (Y-HS); guoh4@upmc.edu (HG); dlau@bidmc.harvard.edu (DTYL)

  Affiliation Liver Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

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• Ying-Hsiu Su

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Writing – original draft, Writing – review & editing

  * E-mail: Ying-hsiu.su@bblumberg.org (Y-HS); guoh4@upmc.edu (HG); dlau@bidmc.harvard.edu (DTYL)

  Affiliation The Baruch S. Blumberg Institute, Translational Medical Science, Doylestown, Pennsylvania, United States of America

  https://orcid.org/0000-0003-0969-0215

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