AI-guided prefusion stabilization of the human coronavirus OC43 spike protein enables universal embecovirus antigen design

• Jelle M. Melchers,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Virology Section, Infectious Diseases and Immunology Division, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Janssen Vaccines & Prevention BV, Leiden, The Netherlands

  ⨯
• Jarek Juraszek,

  Roles Investigation, Methodology, Writing – review & editing

  Current affiliation: Avidicure BV, Oegstgeest, The Netherlands

  Affiliation Janssen Vaccines & Prevention BV, Leiden, The Netherlands

  ⨯
• Ruben J.G. Hulswit,

  Roles Investigation, Visualization, Writing – review & editing

  Affiliation Virology Section, Infectious Diseases and Immunology Division, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands

  ⨯
• Daan van Overveld,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Janssen Vaccines & Prevention BV, Leiden, The Netherlands

  ⨯
• Lam Le,

  Roles Investigation, Writing – review & editing

  Affiliation Janssen Vaccines & Prevention BV, Leiden, The Netherlands

  ⨯
• Frank J.M. van Kuppeveld,

  Roles Investigation, Writing – review & editing

  Affiliation Virology Section, Infectious Diseases and Immunology Division, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands

  ⨯
• Daniel L. Hurdiss,

  Roles Data curation, Formal analysis, Investigation, Methodology, Supervision, Visualization, Writing – review & editing

  Affiliation Virology Section, Infectious Diseases and Immunology Division, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands

  ⨯
• Berend-Jan Bosch,

  Roles Investigation, Supervision, Writing – review & editing

  Affiliation Virology Section, Infectious Diseases and Immunology Division, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands

  ⨯
• Johannes P.M. Langedijk,

  Roles Conceptualization, Formal analysis, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Janssen Vaccines & Prevention BV, Leiden, The Netherlands, ForgeBio BV, Amsterdam, The Netherlands

  ⨯
• Mark J.G. Bakkers

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: mbakkers@forge-bio.com

  Affiliations Janssen Vaccines & Prevention BV, Leiden, The Netherlands, ForgeBio BV, Amsterdam, The Netherlands

  https://orcid.org/0000-0001-8957-1392

  ⨯