Structures of nucleotide-bound Redondovirus Rep protein link conformation and function

Saira Montermoso; Kushol Gupta; Ruth Anne Pumroy; Vera Moiseenkova-Bell; Frederic D. Bushman; Gregory D. Van Duyne

doi:10.1371/journal.ppat.1013997

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Open Access

Peer-reviewed

Research Article

Structures of nucleotide-bound Redondovirus Rep protein link conformation and function

Saira Montermoso,

Roles Formal analysis, Investigation, Writing – review & editing

Affiliations Graduate Group in Biochemistry and Molecular Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

https://orcid.org/0000-0002-8494-9162

⨯
Kushol Gupta,

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

https://orcid.org/0000-0002-7006-2667

⨯
Ruth Anne Pumroy,

Roles Formal analysis, Methodology

Affiliation Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

https://orcid.org/0000-0002-6200-6083

⨯
Vera Moiseenkova-Bell,

Roles Formal analysis, Methodology, Supervision

Affiliation Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

https://orcid.org/0000-0002-0589-4053

⨯
Frederic D. Bushman ,

Roles Conceptualization, Project administration, Supervision, Writing – review & editing

* E-mail: bushman@pennmedicine.upenn.edu (FDB); vanduyne@upenn.edu (GDVD)

Affiliation Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

https://orcid.org/0000-0003-4740-4056

⨯
Gregory D. Van Duyne

Roles Conceptualization, Formal analysis, Project administration, Supervision, Writing – original draft

* E-mail: bushman@pennmedicine.upenn.edu (FDB); vanduyne@upenn.edu (GDVD)

Affiliation Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

https://orcid.org/0000-0003-0247-1626

⨯

Structures of nucleotide-bound Redondovirus Rep protein link conformation and function

Saira Montermoso,
Kushol Gupta,
Ruth Anne Pumroy,
Vera Moiseenkova-Bell,
Frederic D. Bushman,
Gregory D. Van Duyne

Published: March 4, 2026
https://doi.org/10.1371/journal.ppat.1013997

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