Host-directed broad-spectrum immunotherapeutic strategy for respiratory infections: Heat-killed Caulobacter crescentus (HKCC) as an innate-immune based biotherapeutic/postbiotic

• Shanika Werellagama,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Surgery, Faculty of Medicine and Dentistry, College of Health Sciences, University of Alberta, Edmonton, Alberta, Canada

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• Raj S. Patel,

  Roles Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

  Affiliation Department of Surgery, Faculty of Medicine and Dentistry, College of Health Sciences, University of Alberta, Edmonton, Alberta, Canada

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• Nancy Gupta,

  Roles Investigation, Methodology

  Current Affiliations: Independent Scientist, Edmonton, Alberta, Canada,

  Affiliation Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, College of Health Sciences, University of Alberta, Edmonton, Alberta, Canada

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• Satish Vedi,

  Roles Investigation, Methodology

  Current Affiliations: Independent Scientist, Edmonton, Alberta, Canada,

  Affiliation Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, College of Health Sciences, University of Alberta, Edmonton, Alberta, Canada

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• Diana Duque,

  Roles Investigation, Methodology

  Affiliation Infectious Diseases, Human Health Therapeutics Research Centre, National Research Council Canada, Ottawa, Ontario, Canada

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• Jegarubee Bavananthasivam,

  Roles Investigation, Methodology

  Affiliation Infectious Diseases, Human Health Therapeutics Research Centre, National Research Council Canada, Ottawa, Ontario, Canada

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• Rakesh Kumar,

  Roles Conceptualization, Resources, Validation, Writing – review & editing

  Current Affiliations: Professor (Retd.), University of Alberta, Edmonton, Alberta, Canada,; Current Affiliations: ImMed Biotechnologies, Edmonton, Alberta, Canada

  Affiliation Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, College of Health Sciences, University of Alberta, Edmonton, Alberta, Canada

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• Anh Tran,

  Roles Investigation, Methodology, Resources, Supervision, Validation

  Affiliations Infectious Diseases, Human Health Therapeutics Research Centre, National Research Council Canada, Ottawa, Ontario, Canada, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada

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• Babita Agrawal

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: bagrawal@ualberta.ca

  Affiliation Department of Surgery, Faculty of Medicine and Dentistry, College of Health Sciences, University of Alberta, Edmonton, Alberta, Canada

  https://orcid.org/0000-0002-1957-6371

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