The 3C-like serine protease activity of porcine astrovirus nsP1a/3 mediates mitochondrial apoptosis and MAVS cleavage to facilitate viral replication and antagonize type I interferon response

• YiYang Du ,

  Contributed equally to this work with: YiYang Du, Yueqing Lv

  Roles Conceptualization, Investigation, Project administration, Writing – original draft

  Affiliations Laboratory of Animal Infectious Diseases and Molecular Immunology, College of Animal Science and Technology, Guangxi University, Nanning, China, Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics,, Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Nanning, China

  ⨯
• Yueqing Lv ,

  Contributed equally to this work with: YiYang Du, Yueqing Lv

  Roles Conceptualization, Investigation, Methodology, Project administration

  Affiliations Laboratory of Animal Infectious Diseases and Molecular Immunology, College of Animal Science and Technology, Guangxi University, Nanning, China, Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics,, Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Nanning, China

  ⨯
• Xiaoying Feng,

  Roles Methodology

  Affiliations Laboratory of Animal Infectious Diseases and Molecular Immunology, College of Animal Science and Technology, Guangxi University, Nanning, China, Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics,, Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Nanning, China

  ⨯
• Yuhang Luo,

  Roles Data curation

  Affiliations Laboratory of Animal Infectious Diseases and Molecular Immunology, College of Animal Science and Technology, Guangxi University, Nanning, China, Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics,, Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Nanning, China

  ⨯
• Xiaofang Wei,

  Roles Software

  Affiliations Laboratory of Animal Infectious Diseases and Molecular Immunology, College of Animal Science and Technology, Guangxi University, Nanning, China, Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics,, Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Nanning, China

  ⨯
• Sixiao Shao,

  Roles Methodology

  Affiliations Laboratory of Animal Infectious Diseases and Molecular Immunology, College of Animal Science and Technology, Guangxi University, Nanning, China, Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics,, Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Nanning, China

  ⨯
• Yeli Zhou,

  Roles Software

  Affiliations Laboratory of Animal Infectious Diseases and Molecular Immunology, College of Animal Science and Technology, Guangxi University, Nanning, China, Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics,, Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Nanning, China

  ⨯
• Kang Ouyang,

  Roles Supervision

  Affiliations Laboratory of Animal Infectious Diseases and Molecular Immunology, College of Animal Science and Technology, Guangxi University, Nanning, China, Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics,, Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Nanning, China

  ⨯
• Yeshi Yin,

  Roles Formal analysis

  Affiliations Laboratory of Animal Infectious Diseases and Molecular Immunology, College of Animal Science and Technology, Guangxi University, Nanning, China, Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics,, Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Nanning, China

  ⨯
• Ying Chen,

  Roles Data curation

  Affiliations Laboratory of Animal Infectious Diseases and Molecular Immunology, College of Animal Science and Technology, Guangxi University, Nanning, China, Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics,, Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Nanning, China

  ⨯
• Zuzhang Wei,

  Roles Validation

  Affiliations Laboratory of Animal Infectious Diseases and Molecular Immunology, College of Animal Science and Technology, Guangxi University, Nanning, China, Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics,, Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Nanning, China

  ⨯
• Weijian Huang,

  Roles Resources, Supervision

  Affiliations Laboratory of Animal Infectious Diseases and Molecular Immunology, College of Animal Science and Technology, Guangxi University, Nanning, China, Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics,, Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Nanning, China

  ⨯
• Yifeng Qin

  Roles Funding acquisition, Methodology, Project administration, Writing – review & editing

  * E-mail: qinyf@gxu.edu.cn

  Affiliations Laboratory of Animal Infectious Diseases and Molecular Immunology, College of Animal Science and Technology, Guangxi University, Nanning, China, Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics,, Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Nanning, China

  https://orcid.org/0000-0002-2486-6154

  ⨯