Crustacean Mab21 proteins drive tissue-specific antiviral immunity by activating IKKε outside the canonical nucleic-acid sensing paradigm

Haoyang Li; Qinyao Li; Hao Yang; Xiaodi Wang; Airong Lv; Xuanzheng Di; Ranran Wang; Sheng Wang; Bin Yin; Jianguo He; Chaozheng Li

doi:10.1371/journal.ppat.1013986

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Open Access

Peer-reviewed

Research Article

Crustacean Mab21 proteins drive tissue-specific antiviral immunity by activating IKKε outside the canonical nucleic-acid sensing paradigm

Haoyang Li,

Roles Data curation, Funding acquisition, Methodology, Resources, Supervision, Validation, Writing – original draft

Affiliations State Key Laboratory of Biocontrol/ Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), School of Life Sciences, School of Marine Sciences, Sun Yat-sen University, Guangzhou, China, China-ASEAN Belt and Road Joint Laboratory on Mariculture Technology, Sun Yat-sen University, Guangzhou, China, Guangdong Provincial Key Laboratory of Aquatic Economic Animals, Sun Yat-sen University, Guangzhou, China
⨯
Qinyao Li,

Roles Formal analysis, Methodology

Affiliations State Key Laboratory of Biocontrol/ Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), School of Life Sciences, School of Marine Sciences, Sun Yat-sen University, Guangzhou, China, China-ASEAN Belt and Road Joint Laboratory on Mariculture Technology, Sun Yat-sen University, Guangzhou, China, Guangdong Provincial Key Laboratory of Aquatic Economic Animals, Sun Yat-sen University, Guangzhou, China
⨯
Hao Yang,

Roles Formal analysis, Methodology

Affiliations State Key Laboratory of Biocontrol/ Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), School of Life Sciences, School of Marine Sciences, Sun Yat-sen University, Guangzhou, China, China-ASEAN Belt and Road Joint Laboratory on Mariculture Technology, Sun Yat-sen University, Guangzhou, China, Guangdong Provincial Key Laboratory of Aquatic Economic Animals, Sun Yat-sen University, Guangzhou, China
⨯
Xiaodi Wang,

Roles Formal analysis, Methodology

Affiliations State Key Laboratory of Biocontrol/ Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), School of Life Sciences, School of Marine Sciences, Sun Yat-sen University, Guangzhou, China, China-ASEAN Belt and Road Joint Laboratory on Mariculture Technology, Sun Yat-sen University, Guangzhou, China, Guangdong Provincial Key Laboratory of Aquatic Economic Animals, Sun Yat-sen University, Guangzhou, China
⨯
Airong Lv,

Roles Formal analysis, Methodology

Affiliations State Key Laboratory of Biocontrol/ Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), School of Life Sciences, School of Marine Sciences, Sun Yat-sen University, Guangzhou, China, China-ASEAN Belt and Road Joint Laboratory on Mariculture Technology, Sun Yat-sen University, Guangzhou, China, Guangdong Provincial Key Laboratory of Aquatic Economic Animals, Sun Yat-sen University, Guangzhou, China
⨯
Xuanzheng Di,

Roles Methodology, Software

Affiliations State Key Laboratory of Biocontrol/ Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), School of Life Sciences, School of Marine Sciences, Sun Yat-sen University, Guangzhou, China, China-ASEAN Belt and Road Joint Laboratory on Mariculture Technology, Sun Yat-sen University, Guangzhou, China, Guangdong Provincial Key Laboratory of Aquatic Economic Animals, Sun Yat-sen University, Guangzhou, China
⨯
Ranran Wang,

Roles Formal analysis, Methodology

Affiliations State Key Laboratory of Biocontrol/ Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), School of Life Sciences, School of Marine Sciences, Sun Yat-sen University, Guangzhou, China, China-ASEAN Belt and Road Joint Laboratory on Mariculture Technology, Sun Yat-sen University, Guangzhou, China, Guangdong Provincial Key Laboratory of Aquatic Economic Animals, Sun Yat-sen University, Guangzhou, China
⨯
Sheng Wang,

Roles Data curation, Funding acquisition, Methodology

Affiliations State Key Laboratory of Biocontrol/ Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), School of Life Sciences, School of Marine Sciences, Sun Yat-sen University, Guangzhou, China, China-ASEAN Belt and Road Joint Laboratory on Mariculture Technology, Sun Yat-sen University, Guangzhou, China, Guangdong Provincial Key Laboratory of Aquatic Economic Animals, Sun Yat-sen University, Guangzhou, China
⨯
Bin Yin,

Roles Investigation, Methodology, Software

Affiliations State Key Laboratory of Biocontrol/ Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), School of Life Sciences, School of Marine Sciences, Sun Yat-sen University, Guangzhou, China, China-ASEAN Belt and Road Joint Laboratory on Mariculture Technology, Sun Yat-sen University, Guangzhou, China, Guangdong Provincial Key Laboratory of Aquatic Economic Animals, Sun Yat-sen University, Guangzhou, China
⨯
Jianguo He ,

Roles Funding acquisition, Project administration, Validation

* E-mail: lsshjg@mail.sysu.edu.cn (JH); lichaozh@mail2.sysu.edu.cn (CL)

Affiliations State Key Laboratory of Biocontrol/ Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), School of Life Sciences, School of Marine Sciences, Sun Yat-sen University, Guangzhou, China, China-ASEAN Belt and Road Joint Laboratory on Mariculture Technology, Sun Yat-sen University, Guangzhou, China, Guangdong Provincial Key Laboratory of Aquatic Economic Animals, Sun Yat-sen University, Guangzhou, China
⨯
Chaozheng Li

Roles Funding acquisition, Investigation, Project administration, Supervision, Validation, Writing – review & editing

* E-mail: lsshjg@mail.sysu.edu.cn (JH); lichaozh@mail2.sysu.edu.cn (CL)

Affiliations State Key Laboratory of Biocontrol/ Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), School of Life Sciences, School of Marine Sciences, Sun Yat-sen University, Guangzhou, China, China-ASEAN Belt and Road Joint Laboratory on Mariculture Technology, Sun Yat-sen University, Guangzhou, China, Guangdong Provincial Key Laboratory of Aquatic Economic Animals, Sun Yat-sen University, Guangzhou, China

https://orcid.org/0000-0001-7639-7831

⨯

Crustacean Mab21 proteins drive tissue-specific antiviral immunity by activating IKKε outside the canonical nucleic-acid sensing paradigm

Haoyang Li,
Qinyao Li,
Hao Yang,
Xiaodi Wang,
Airong Lv,
Xuanzheng Di,
Ranran Wang,
Sheng Wang,
Bin Yin,
Jianguo He

Published: February 17, 2026
https://doi.org/10.1371/journal.ppat.1013986

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