An intrinsic loop-mediated structural stability modulating inhibitor potency in the SADS-CoV and SARS-CoV-2 main proteases

• Rui Zeng ,

  Contributed equally to this work with: Rui Zeng, Shizhan Cui, Xiaoyan Xia, Chong Huang

  Roles Formal analysis, Investigation, Project administration, Validation, Visualization, Writing – original draft

  Affiliation National Clinical Research Center for Geriatrics, and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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• Shizhan Cui ,

  Contributed equally to this work with: Rui Zeng, Shizhan Cui, Xiaoyan Xia, Chong Huang

  Roles Formal analysis, Investigation, Validation, Visualization, Writing – original draft

  Affiliation Clinical Stem Cell Research Center, Peking University Third Hospital, Beijing, China

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• Xiaoyan Xia ,

  Contributed equally to this work with: Rui Zeng, Shizhan Cui, Xiaoyan Xia, Chong Huang

  Roles Formal analysis, Investigation, Methodology, Validation

  Affiliation National Clinical Research Center for Geriatrics, and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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• Chong Huang ,

  Contributed equally to this work with: Rui Zeng, Shizhan Cui, Xiaoyan Xia, Chong Huang

  Roles Investigation

  Affiliation National Clinical Research Center for Geriatrics, and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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• Jingxuan Sun,

  Roles Investigation

  Affiliation National Clinical Research Center for Geriatrics, and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China

  ⨯
• Xinyue Deng,

  Roles Investigation

  Affiliation National Clinical Research Center for Geriatrics, and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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• Qiaoling Gui,

  Roles Investigation

  Affiliation National Clinical Research Center for Geriatrics, and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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• Huahao Fan,

  Roles Resources

  Affiliation School of Life Sciences, Tianjin University, Tianjin, China

  ⨯
• Xiaojuan Liu,

  Roles Formal analysis, Investigation, Methodology, Resources, Writing – original draft

  Affiliation Clinical Stem Cell Research Center, Peking University Third Hospital, Beijing, China

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• Yang Yu ,

  Roles Conceptualization, Funding acquisition, Resources, Writing – review & editing

  * E-mail: yuyang5012@hotmail.com (YY); yangsy@scu.edu.cn (SY); leijian@scu.edu.cn (JL)

  Affiliations Clinical Stem Cell Research Center, Peking University Third Hospital, Beijing, China, Beijing Advanced Center of Cellular Homeostasis and Aging-Related Diseases Institute of Advanced Clinical Medicine, Peking University, Beijing, China, Frontiers Medical Center, Tianfu Jincheng Laboratory, Chengdu, Sichuan, China

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• Shengyong Yang ,

  Roles Conceptualization, Funding acquisition, Resources, Writing – review & editing

  * E-mail: yuyang5012@hotmail.com (YY); yangsy@scu.edu.cn (SY); leijian@scu.edu.cn (JL)

  Affiliation National Clinical Research Center for Geriatrics, and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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• Jian Lei

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: yuyang5012@hotmail.com (YY); yangsy@scu.edu.cn (SY); leijian@scu.edu.cn (JL)

  Affiliation National Clinical Research Center for Geriatrics, and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China

  https://orcid.org/0000-0001-9326-0554

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