RSAD2/VIPERIN and CMPK2 coordinate an immunometabolic response to Epstein-Barr Virus

Urvi S. Zankharia; Adam M. Glass; Wujuan Zhang; Qing Zhu; Janvhi Suresh Machhar; Ying Ye; Bhanu Chandra Karisetty; Jayamanna Wickramasinghe; Andrew Kossenkov; Jozef Madzo; Sun Sook Chung; Samantha S. Soldan; Richard Jason Lamontagne; James M. Wood; Lawrence D. Harris; Tyler L. Grove; Steven Jacobson; Aaron R. Goldman; Chengyu Liang; Paul M. Lieberman

doi:10.1371/journal.ppat.1013973

Loading metrics

Open Access

Peer-reviewed

Research Article

RSAD2/VIPERIN and CMPK2 coordinate an immunometabolic response to Epstein-Barr Virus

Urvi S. Zankharia,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

Affiliation The Wistar Institute, Philadelphia, Pennsylvania, United States of America
⨯
Adam M. Glass,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation The Wistar Institute, Philadelphia, Pennsylvania, United States of America
⨯
Wujuan Zhang,

Roles Formal analysis, Investigation, Methodology, Visualization

Affiliation The Wistar Institute, Philadelphia, Pennsylvania, United States of America
⨯
Qing Zhu,

Roles Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

Affiliation The Wistar Institute, Philadelphia, Pennsylvania, United States of America
⨯
Janvhi Suresh Machhar,

Roles Investigation

Affiliation The Wistar Institute, Philadelphia, Pennsylvania, United States of America
⨯
Ying Ye,

Roles Investigation

Affiliation The Wistar Institute, Philadelphia, Pennsylvania, United States of America
⨯
Bhanu Chandra Karisetty,

Roles Data curation, Formal analysis, Methodology, Visualization

Affiliation The Wistar Institute, Philadelphia, Pennsylvania, United States of America
⨯
Jayamanna Wickramasinghe,

Roles Data curation, Formal analysis, Methodology, Supervision, Visualization, Writing – original draft

Affiliation The Wistar Institute, Philadelphia, Pennsylvania, United States of America
⨯
Andrew Kossenkov,

Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

Affiliation The Wistar Institute, Philadelphia, Pennsylvania, United States of America
⨯
Jozef Madzo,

Roles Data curation, Formal analysis, Methodology, Supervision, Validation

Affiliation The Wistar Institute, Philadelphia, Pennsylvania, United States of America
⨯
Sun Sook Chung,

Roles Formal analysis, Methodology, Validation

Affiliation The Wistar Institute, Philadelphia, Pennsylvania, United States of America

https://orcid.org/0000-0002-7340-3359

⨯
Samantha S. Soldan,

Roles Formal analysis, Investigation, Methodology, Validation

Affiliation The Wistar Institute, Philadelphia, Pennsylvania, United States of America
⨯
Richard Jason Lamontagne,

Roles Formal analysis, Investigation, Methodology

Affiliation The Wistar Institute, Philadelphia, Pennsylvania, United States of America
⨯
James M. Wood,

Roles Investigation, Methodology, Resources

Affiliation Victoria University of Wellington, Wellington, New Zealand

https://orcid.org/0000-0002-5965-1006

⨯
Lawrence D. Harris,

Roles Methodology, Resources

Affiliation Victoria University of Wellington, Wellington, New Zealand
⨯
Tyler L. Grove,

Roles Investigation, Methodology, Resources

Affiliation Albert Einstein School of Medicine, New York, New York, United States of America
⨯
Steven Jacobson,

Roles Investigation, Methodology, Resources

Affiliation NINDS, NIH, Bethesda, Maryland, United States of America
⨯
Aaron R. Goldman,

Roles Data curation, Formal analysis, Investigation, Methodology, Supervision, Visualization

Affiliation The Wistar Institute, Philadelphia, Pennsylvania, United States of America

https://orcid.org/0000-0001-7605-9592

⨯
Chengyu Liang,

Roles Conceptualization, Investigation, Methodology, Resources, Supervision

Affiliation The Wistar Institute, Philadelphia, Pennsylvania, United States of America
⨯
[ ... ],
Paul M. Lieberman

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: lieberman@wistar.org

Affiliation The Wistar Institute, Philadelphia, Pennsylvania, United States of America

https://orcid.org/0000-0002-3935-9921

⨯
[ view all ]
[ view less ]

RSAD2/VIPERIN and CMPK2 coordinate an immunometabolic response to Epstein-Barr Virus

Urvi S. Zankharia,
Adam M. Glass,
Wujuan Zhang,
Qing Zhu,
Janvhi Suresh Machhar,
Ying Ye,
Bhanu Chandra Karisetty,
Jayamanna Wickramasinghe,
Andrew Kossenkov,
Jozef Madzo

Published: August 3, 2026
https://doi.org/10.1371/journal.ppat.1013973

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Mitochondria
Is the Subject Area "Mitochondria" applicable to this article?

Thanks for your feedback.
Viral replication
Is the Subject Area "Viral replication" applicable to this article?

Thanks for your feedback.
Epstein-Barr virus
Is the Subject Area "Epstein-Barr virus" applicable to this article?

Thanks for your feedback.
Apoptosis
Is the Subject Area "Apoptosis" applicable to this article?

Thanks for your feedback.
Metabolites
Is the Subject Area "Metabolites" applicable to this article?

Thanks for your feedback.
B cells
Is the Subject Area "B cells" applicable to this article?

Thanks for your feedback.
Gene regulation
Is the Subject Area "Gene regulation" applicable to this article?

Thanks for your feedback.
Cell signaling
Is the Subject Area "Cell signaling" applicable to this article?

Thanks for your feedback.