Breaking disulfide bonds in a weakly bactericidal α-defensin unleashes a potent antimicrobial peptide with an altered conformation

• Gan Luo ,

  Contributed equally to this work with: Gan Luo, Mingzhu Zhao

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Shanghai Institute of Infectious Disease and Biosecurity, Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Science, Fudan University, Shanghai, China

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• Mingzhu Zhao ,

  Contributed equally to this work with: Gan Luo, Mingzhu Zhao

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization

  Affiliation Shanghai Institute of Infectious Disease and Biosecurity, Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Science, Fudan University, Shanghai, China

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• Qingxia Wang,

  Roles Conceptualization, Validation

  Affiliations Shanghai Institute of Infectious Disease and Biosecurity, Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Science, Fudan University, Shanghai, China, Key Laboratory of Smart Drug Delivery (MOE), School of Pharmacy, Fudan University, Shanghai, China

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• Yang Zhou,

  Roles Investigation

  Affiliation Shanghai Institute of Infectious Disease and Biosecurity, Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Science, Fudan University, Shanghai, China

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• Dan Yao,

  Roles Investigation

  Affiliation Shanghai Institute of Infectious Disease and Biosecurity, Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Science, Fudan University, Shanghai, China

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• Jue Zhang,

  Roles Investigation

  Affiliation Shanghai Institute of Infectious Disease and Biosecurity, Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Science, Fudan University, Shanghai, China

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• Gang Wang,

  Roles Investigation

  Affiliation Shanghai Institute of Infectious Disease and Biosecurity, Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Science, Fudan University, Shanghai, China

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• Junjie Zhang,

  Roles Investigation

  Affiliation Shanghai Institute of Infectious Disease and Biosecurity, Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Science, Fudan University, Shanghai, China

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• Chongbing Liao,

  Roles Funding acquisition, Writing – review & editing

  Affiliation Shanghai Institute of Infectious Disease and Biosecurity, Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Science, Fudan University, Shanghai, China

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• Wuyuan Lu

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: luwuyuan@fudan.edu.cn

  Affiliation Shanghai Institute of Infectious Disease and Biosecurity, Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Science, Fudan University, Shanghai, China

  https://orcid.org/0000-0003-1318-9968

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