A novel SO2 probe inhibits lysophagy induced by Senecavirus A infection by promoting LAMP1 Cys375 sulfenylation

Shuo Wang; WenWen Han; BaoXiang Zhao; Ye Hong; Jun Li; JunYing Miao; ZhaoMin Lin

doi:10.1371/journal.ppat.1013932

Loading metrics

Open Access

Peer-reviewed

Research Article

A novel SO₂ probe inhibits lysophagy induced by Senecavirus A infection by promoting LAMP1 Cys375 sulfenylation

Shuo Wang,

Roles Data curation, Writing – original draft

Affiliations Shandong Provincial Key Laboratory of Development and Regeneration, School of Life Science, Shandong University, Qingdao, P.R. China, Key Laboratory of Livestock and Poultry Multi-omics of MARA, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan, P.R. China
⨯
WenWen Han,

Roles Data curation

Affiliation Shandong Provincial Key Laboratory of Development and Regeneration, School of Life Science, Shandong University, Qingdao, P.R. China
⨯
BaoXiang Zhao,

Roles Resources

Affiliation Institute of Organic Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan, P.R. China
⨯
Ye Hong ,

Roles Writing – review & editing

* E-mail: hongye@sdu.edu.cn (YH); junli79@163.com (JL); miaojy@sdu.edu.cn (JYM); linzhaomin@sdu.edu.cn (ZML)

Affiliation Shandong Provincial Key Laboratory of Development and Regeneration, School of Life Science, Shandong University, Qingdao, P.R. China
⨯
Jun Li ,

Roles Resources, Writing – review & editing

* E-mail: hongye@sdu.edu.cn (YH); junli79@163.com (JL); miaojy@sdu.edu.cn (JYM); linzhaomin@sdu.edu.cn (ZML)

Affiliation Key Laboratory of Livestock and Poultry Multi-omics of MARA, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan, P.R. China
⨯
JunYing Miao ,

Roles Conceptualization, Resources, Writing – review & editing

* E-mail: hongye@sdu.edu.cn (YH); junli79@163.com (JL); miaojy@sdu.edu.cn (JYM); linzhaomin@sdu.edu.cn (ZML)

Affiliations Shandong Provincial Key Laboratory of Development and Regeneration, School of Life Science, Shandong University, Qingdao, P.R. China, State Key Laboratory of Microbial Technology (Microbial Technology Institute), Shandong University, Qingdao, P.R. China
⨯
ZhaoMin Lin

Roles Conceptualization, Writing – review & editing

* E-mail: hongye@sdu.edu.cn (YH); junli79@163.com (JL); miaojy@sdu.edu.cn (JYM); linzhaomin@sdu.edu.cn (ZML)

Affiliation Institute of Medical Science, the Second Hospital of Shandong University, Jinan, P.R. China
⨯

A novel SO₂ probe inhibits lysophagy induced by Senecavirus A infection by promoting LAMP1 Cys375 sulfenylation

Shuo Wang,
WenWen Han,
BaoXiang Zhao,
Ye Hong,
Jun Li,
JunYing Miao,
ZhaoMin Lin

Published: February 5, 2026
https://doi.org/10.1371/journal.ppat.1013932

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Lysosomes
Is the Subject Area "Lysosomes" applicable to this article?

Thanks for your feedback.
Autophagic cell death
Is the Subject Area "Autophagic cell death" applicable to this article?

Thanks for your feedback.
Ubiquitination
Is the Subject Area "Ubiquitination" applicable to this article?

Thanks for your feedback.
Viral replication
Is the Subject Area "Viral replication" applicable to this article?

Thanks for your feedback.
Cysteine
Is the Subject Area "Cysteine" applicable to this article?

Thanks for your feedback.
Transfection
Is the Subject Area "Transfection" applicable to this article?

Thanks for your feedback.
Antivirals
Is the Subject Area "Antivirals" applicable to this article?

Thanks for your feedback.
Viral transmission and infection
Is the Subject Area "Viral transmission and infection" applicable to this article?

Thanks for your feedback.