Viral inhibition of the anaphase promoting complex enhances replication by elevating nucleotide pools

• Owen J. Chen ,

  Contributed equally to this work with: Owen J. Chen, Cynthia Y. Feng

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

  Affiliations Rosalind and Morris Goodman Cancer Institute, McGill University, Montréal, Québec, Canada, Department of Biochemistry, McGill University, Montréal, Québec, Canada

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• Cynthia Y. Feng ,

  Contributed equally to this work with: Owen J. Chen, Cynthia Y. Feng

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

  Affiliations Rosalind and Morris Goodman Cancer Institute, McGill University, Montréal, Québec, Canada, Department of Biochemistry, McGill University, Montréal, Québec, Canada

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• Paola Blanchette,

  Roles Methodology, Resources, Investigation

  Affiliation Rosalind and Morris Goodman Cancer Institute, McGill University, Montréal, Québec, Canada

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• Reese Jalal Ladak,

  Roles Investigation

  Affiliations Rosalind and Morris Goodman Cancer Institute, McGill University, Montréal, Québec, Canada, Department of Biochemistry, McGill University, Montréal, Québec, Canada

  ⨯
• Maximilian A. Crosby,

  Roles Investigation

  Affiliations Rosalind and Morris Goodman Cancer Institute, McGill University, Montréal, Québec, Canada, Department of Microbiology and Immunology, McGill University, Montréal, Québec, Canada

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• Mariana de Sá Tavares Russo,

  Roles Investigation

  Affiliation Rosalind and Morris Goodman Cancer Institute, McGill University, Montréal, Québec, Canada

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• Yilin Wang,

  Roles Investigation

  Affiliations Rosalind and Morris Goodman Cancer Institute, McGill University, Montréal, Québec, Canada, Department of Biochemistry, McGill University, Montréal, Québec, Canada

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• Cristina Fernandez,

  Roles Investigation

  Affiliations Rosalind and Morris Goodman Cancer Institute, McGill University, Montréal, Québec, Canada, Department of Biochemistry, McGill University, Montréal, Québec, Canada

  ⨯
• Yingke Liang,

  Roles Investigation

  Affiliations Rosalind and Morris Goodman Cancer Institute, McGill University, Montréal, Québec, Canada, Department of Biochemistry, McGill University, Montréal, Québec, Canada

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• David M. Sharon,

  Roles Conceptualization, Investigation, Methodology

  Affiliations Rosalind and Morris Goodman Cancer Institute, McGill University, Montréal, Québec, Canada, Department of Microbiology and Immunology, McGill University, Montréal, Québec, Canada

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• Mohamed Moustafa-Kamal,

  Roles Resources

  Affiliation Rosalind and Morris Goodman Cancer Institute, McGill University, Montréal, Québec, Canada

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• Isabelle Gamache,

  Roles Methodology, Resources

  Affiliation Rosalind and Morris Goodman Cancer Institute, McGill University, Montréal, Québec, Canada

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• Nahum Sonenberg,

  Roles Supervision

  Affiliations Rosalind and Morris Goodman Cancer Institute, McGill University, Montréal, Québec, Canada, Department of Biochemistry, McGill University, Montréal, Québec, Canada

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• Daina Avizonis,

  Roles Investigation, Resources, Supervision

  Affiliation Rosalind and Morris Goodman Cancer Institute, McGill University, Montréal, Québec, Canada

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• Jose G. Teodoro

  Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: jose.teodoro@mcgill.ca

  Affiliations Rosalind and Morris Goodman Cancer Institute, McGill University, Montréal, Québec, Canada, Department of Biochemistry, McGill University, Montréal, Québec, Canada, Department of Microbiology and Immunology, McGill University, Montréal, Québec, Canada

  https://orcid.org/0000-0002-3713-6839

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