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Open Access
Peer-reviewed
Research Article
The host protein cyclophilin A restricts nuclear entry of HIV-1 mutants by reducing the elasticity of the viral capsid
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Jun Hong ,
Contributed equally to this work with: Jun Hong, Akshay Deshpande
Roles Data curation, Investigation, Methodology
Affiliation Vanderbilt University Medical Center, Department of Pathology, Microbiology and Immunology and Vanderbilt Institute for Infection, Immunology, and Inflammation, Nashville, Tennessee, United States of America
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Akshay Deshpande ,
Contributed equally to this work with: Jun Hong, Akshay Deshpande
Roles Formal analysis, Investigation, Methodology, Validation
Affiliation Ben-Gurion University of the Negev, Department of Physiology and Cell Biology, Beersheva, Israel
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Yatish Thakare,
Roles Investigation
Affiliation Ben-Gurion University of the Negev, Department of Physiology and Cell Biology, Beersheva, Israel
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Lora Simonovsky,
Roles Investigation
Affiliation Ben-Gurion University of the Negev, Department of Physiology and Cell Biology, Beersheva, Israel
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AidanDarian W. Douglas,
Roles Investigation
Affiliation Department of Biological Sciences and Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida, United States of America
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Conall Mc Guinness,
Roles Investigation
Affiliation EMBL Australia Node in Single Molecule Science, School of Biomedical Sciences, UNSW, Sydney, Australia
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Noa Rotem-Dai,
Roles Investigation
Affiliation Ben-Gurion University of the Negev, Department of Physiology and Cell Biology, Beersheva, Israel
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Michelle L. Kortyna,
Roles Investigation
Affiliation Department of Biological Sciences and Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida, United States of America
⨯ - J. Ole Klarhof,
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Jiong Shi,
Roles Resources
Affiliation Vanderbilt University Medical Center, Department of Pathology, Microbiology and Immunology and Vanderbilt Institute for Infection, Immunology, and Inflammation, Nashville, Tennessee, United States of America
⨯ - Leo C. James,
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Till Boecking,
Roles Investigation, Methodology, Validation, Writing – review & editing
Affiliation EMBL Australia Node in Single Molecule Science, School of Biomedical Sciences, UNSW, Sydney, Australia
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Ashwanth C. Francis,
Roles Investigation, Methodology, Supervision, Validation, Writing – original draft, Writing – review & editing
Affiliation Department of Biological Sciences and Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida, United States of America
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Itay Rousso ,
Roles Conceptualization, Funding acquisition, Investigation, Methodology, Supervision, Validation, Writing – original draft, Writing – review & editing
* E-mail: roussoi@bgu.ac (IR); chris.aiken@vumc.org (CA)
Affiliation Ben-Gurion University of the Negev, Department of Physiology and Cell Biology, Beersheva, Israel
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Christopher Aiken
Roles Conceptualization, Data curation, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing
* E-mail: roussoi@bgu.ac (IR); chris.aiken@vumc.org (CA)
Affiliation Vanderbilt University Medical Center, Department of Pathology, Microbiology and Immunology and Vanderbilt Institute for Infection, Immunology, and Inflammation, Nashville, Tennessee, United States of America
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The host protein cyclophilin A restricts nuclear entry of HIV-1 mutants by reducing the elasticity of the viral capsid
- Jun Hong,
- Akshay Deshpande,
- Yatish Thakare,
- Lora Simonovsky,
- AidanDarian W. Douglas,
- Conall Mc Guinness,
- Noa Rotem-Dai,
- Michelle L. Kortyna,
- J. Ole Klarhof,
- Jiong Shi
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- Published: January 29, 2026
- https://doi.org/10.1371/journal.ppat.1013910