YAP Inhibits HIV-1 transcription and promotes HIV-1 latency by regulating E3 ubiquitin ligase UHRF1 mediated tat degradation

Chenliang Zhou; Hong He; Yuzai Zhang; Xiaolian Liu; Muye Xia; Jiayin Qiu; Ziyao Wu; Huba Khamis Rashid; Wenli Liu; Jie Peng; Lin Li

doi:10.1371/journal.ppat.1013906

Loading metrics

Open Access

Peer-reviewed

Research Article

YAP Inhibits HIV-1 transcription and promotes HIV-1 latency by regulating E3 ubiquitin ligase UHRF1 mediated tat degradation

Chenliang Zhou ,

Contributed equally to this work with: Chenliang Zhou, Hong He, Yuzai Zhang

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Visualization, Writing – original draft

Affiliations Guangdong Provincial Key Laboratory of New Drug Screening, Key Laboratory of Infectious Diseases Research in South China, Ministry of Education, NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, P. R. China, College of Pharmacy, Nanchang Medical College, Nanchang, P. R. China
⨯
Hong He ,

Contributed equally to this work with: Chenliang Zhou, Hong He, Yuzai Zhang

Roles Data curation, Investigation, Validation

Affiliation Guangdong Provincial Key Laboratory of New Drug Screening, Key Laboratory of Infectious Diseases Research in South China, Ministry of Education, NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, P. R. China
⨯
Yuzai Zhang ,

Contributed equally to this work with: Chenliang Zhou, Hong He, Yuzai Zhang

Roles Data curation, Investigation, Visualization, Writing – review & editing

Affiliation Guangdong Provincial Key Laboratory of New Drug Screening, Key Laboratory of Infectious Diseases Research in South China, Ministry of Education, NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, P. R. China
⨯
Xiaolian Liu,

Roles Data curation, Methodology, Software, Validation

Affiliation The Affiliated Eye Hospital, Jiangxi Medical College, Nanchang University, Nanchang, P. R. China
⨯
Muye Xia,

Roles Resources

Affiliation State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, P. R. China
⨯
Jiayin Qiu,

Roles Funding acquisition

Affiliation Department of Pharmacy, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, P. R. China
⨯
Ziyao Wu,

Roles Investigation, Methodology

Affiliation Guangdong Provincial Key Laboratory of New Drug Screening, Key Laboratory of Infectious Diseases Research in South China, Ministry of Education, NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, P. R. China
⨯
Huba Khamis Rashid,

Roles Investigation

Affiliation Guangdong Provincial Key Laboratory of New Drug Screening, Key Laboratory of Infectious Diseases Research in South China, Ministry of Education, NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, P. R. China
⨯
Wenli Liu,

Roles Investigation

Affiliation Guangdong Provincial Key Laboratory of New Drug Screening, Key Laboratory of Infectious Diseases Research in South China, Ministry of Education, NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, P. R. China
⨯
Jie Peng ,

Roles Resources, Supervision

* E-mail: pjie138@163.com (JP); li75lin@126.com (LL)

Affiliation State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, P. R. China
⨯
Lin Li

Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

* E-mail: pjie138@163.com (JP); li75lin@126.com (LL)

Affiliation Guangdong Provincial Key Laboratory of New Drug Screening, Key Laboratory of Infectious Diseases Research in South China, Ministry of Education, NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, P. R. China

https://orcid.org/0000-0002-2443-3121

⨯

YAP Inhibits HIV-1 transcription and promotes HIV-1 latency by regulating E3 ubiquitin ligase UHRF1 mediated tat degradation

Chenliang Zhou,
Hong He,
Yuzai Zhang,
Xiaolian Liu,
Muye Xia,
Jiayin Qiu,
Ziyao Wu,
Huba Khamis Rashid,
Wenli Liu,
Jie Peng

Published: January 30, 2026
https://doi.org/10.1371/journal.ppat.1013906

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

HIV-1
Is the Subject Area "HIV-1" applicable to this article?

Thanks for your feedback.
Ubiquitination
Is the Subject Area "Ubiquitination" applicable to this article?

Thanks for your feedback.
Transfection
Is the Subject Area "Transfection" applicable to this article?

Thanks for your feedback.
Lysine
Is the Subject Area "Lysine" applicable to this article?

Thanks for your feedback.
Small interfering RNA
Is the Subject Area "Small interfering RNA" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.
Immunoblot analysis
Is the Subject Area "Immunoblot analysis" applicable to this article?

Thanks for your feedback.
Ubiquitin ligases
Is the Subject Area "Ubiquitin ligases" applicable to this article?

Thanks for your feedback.