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Open Access
Peer-reviewed
Research Article
Anti-orthopoxvirus drugs inhibit lumpy skin disease virus replication by targeting viral DNA polymerase
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Zuxin Gong,
Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing
Affiliation Key Laboratory of Animal Diseases Diagnostic and Immunology, Ministry of Agriculture, MOE International Joint Collaborative Research Laboratory for Animal Health & Food Safety, The Belt and Road International Sci-Tech Innovation Institute of Transboundary Animal Disease Diagnosis and Immunization, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China
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Jiaqi Dai,
Roles Data curation, Formal analysis, Methodology, Visualization
Affiliation Key Laboratory of Animal Diseases Diagnostic and Immunology, Ministry of Agriculture, MOE International Joint Collaborative Research Laboratory for Animal Health & Food Safety, The Belt and Road International Sci-Tech Innovation Institute of Transboundary Animal Disease Diagnosis and Immunization, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China
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Hailong Qu,
Roles Formal analysis, Methodology
Affiliation China Animal Health and Epidemiology Center, Qingdao, China
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Yongxin Hu,
Roles Formal analysis, Methodology
Affiliation China Animal Health and Epidemiology Center, Qingdao, China
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Fanqi Sun,
Roles Formal analysis
Affiliation Key Laboratory of Animal Diseases Diagnostic and Immunology, Ministry of Agriculture, MOE International Joint Collaborative Research Laboratory for Animal Health & Food Safety, The Belt and Road International Sci-Tech Innovation Institute of Transboundary Animal Disease Diagnosis and Immunization, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China
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Chenchen Liu,
Roles Validation
Affiliation Key Laboratory of Animal Diseases Diagnostic and Immunology, Ministry of Agriculture, MOE International Joint Collaborative Research Laboratory for Animal Health & Food Safety, The Belt and Road International Sci-Tech Innovation Institute of Transboundary Animal Disease Diagnosis and Immunization, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China
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Xin Li,
Roles Validation
Affiliation Key Laboratory of Animal Diseases Diagnostic and Immunology, Ministry of Agriculture, MOE International Joint Collaborative Research Laboratory for Animal Health & Food Safety, The Belt and Road International Sci-Tech Innovation Institute of Transboundary Animal Disease Diagnosis and Immunization, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China
⨯ - Chunyan Feng,
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Zhiliang Wang ,
Roles Project administration, Resources, Writing – review & editing
* E-mail: gliu21@njau.edu.cn (GL); yangzhen@njau.edu.cn (ZY); wangzhiliang@cahec.cn (ZW)
Affiliation China Animal Health and Epidemiology Center, Qingdao, China
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Zhen Yang ,
Roles Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing
* E-mail: gliu21@njau.edu.cn (GL); yangzhen@njau.edu.cn (ZY); wangzhiliang@cahec.cn (ZW)
Affiliation Key Laboratory of Animal Diseases Diagnostic and Immunology, Ministry of Agriculture, MOE International Joint Collaborative Research Laboratory for Animal Health & Food Safety, The Belt and Road International Sci-Tech Innovation Institute of Transboundary Animal Disease Diagnosis and Immunization, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China
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Gongguan Liu
Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing
* E-mail: gliu21@njau.edu.cn (GL); yangzhen@njau.edu.cn (ZY); wangzhiliang@cahec.cn (ZW)
Affiliation Key Laboratory of Animal Diseases Diagnostic and Immunology, Ministry of Agriculture, MOE International Joint Collaborative Research Laboratory for Animal Health & Food Safety, The Belt and Road International Sci-Tech Innovation Institute of Transboundary Animal Disease Diagnosis and Immunization, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China
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Anti-orthopoxvirus drugs inhibit lumpy skin disease virus replication by targeting viral DNA polymerase
- Zuxin Gong,
- Jiaqi Dai,
- Hailong Qu,
- Yongxin Hu,
- Fanqi Sun,
- Chenchen Liu,
- Xin Li,
- Chunyan Feng,
- Zhiliang Wang,
- Zhen Yang
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- Published: January 26, 2026
- https://doi.org/10.1371/journal.ppat.1013903