HCMV encoded UL84 hijacks FHL2 to suppress type I interferon production and enhance viral replication

• Ruilin Li ,

  Contributed equally to this work with: Ruilin Li, Sisi Xia, Xin Li

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft

  Affiliation State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Key Laboratory of Viral Pathogenesis & Infection Prevention and Control, College of Life Science and Technology, College of Pharmacy, Jinan University, Guangzhou, China

  ⨯
• Sisi Xia ,

  Contributed equally to this work with: Ruilin Li, Sisi Xia, Xin Li

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft

  Affiliation Department of Biological Engineering, Wuhan Polytechnic University, Wuhan, China

  ⨯
• Xin Li ,

  Contributed equally to this work with: Ruilin Li, Sisi Xia, Xin Li

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft

  Affiliation State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Key Laboratory of Viral Pathogenesis & Infection Prevention and Control, College of Life Science and Technology, College of Pharmacy, Jinan University, Guangzhou, China

  ⨯
• Ying Zeng,

  Roles Investigation, Methodology

  Affiliation Department of Pathogen Biology and Microecology, College of Basic Medical Sciences, Dalian Medical University, Dalian, China

  ⨯
• Tianqi Wang,

  Roles Investigation, Methodology

  Affiliation Department of Pathogen Biology and Microecology, College of Basic Medical Sciences, Dalian Medical University, Dalian, China

  ⨯
• Chuan Xia ,

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: chenjun@jnu.edu.cn (JC); tlihj@jnu.edu.cn (HL); xiachuan@dmu.edu.cn (CX)

  Affiliation Department of Pathogen Biology and Microecology, College of Basic Medical Sciences, Dalian Medical University, Dalian, China

  ⨯
• Hongjian Li ,

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: chenjun@jnu.edu.cn (JC); tlihj@jnu.edu.cn (HL); xiachuan@dmu.edu.cn (CX)

  Affiliation State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Key Laboratory of Viral Pathogenesis & Infection Prevention and Control, College of Life Science and Technology, College of Pharmacy, Jinan University, Guangzhou, China

  ⨯
• Jun Chen

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: chenjun@jnu.edu.cn (JC); tlihj@jnu.edu.cn (HL); xiachuan@dmu.edu.cn (CX)

  Affiliation State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Key Laboratory of Viral Pathogenesis & Infection Prevention and Control, College of Life Science and Technology, College of Pharmacy, Jinan University, Guangzhou, China

  https://orcid.org/0000-0003-2447-0544

  ⨯