De novo nucleotide biosynthesis and its dynamic regulation are crucial for systemic infection by extraintestinal Escherichia coli

• Chu Zhang ,

  Contributed equally to this work with: Chu Zhang, Yi Yang

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft

  Affiliation National Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China

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• Yi Yang ,

  Contributed equally to this work with: Chu Zhang, Yi Yang

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft

  Affiliation National Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China

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• Shuang Wang,

  Roles Data curation, Formal analysis, Investigation, Methodology

  Affiliation National Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China

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• Yuying Liu,

  Roles Investigation, Methodology

  Affiliation National Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China

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• Xianglin Zhao,

  Roles Investigation, Methodology

  Affiliation National Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China

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• Fan Yin,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliation Institute of Modern Biology, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China

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• Yawen Hu,

  Roles Investigation, Methodology

  Affiliation National Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China

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• Ying Xue,

  Roles Investigation, Methodology

  Affiliation National Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China

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• Zixuan Bu,

  Roles Methodology

  Affiliation National Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China

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• Shaowen Li,

  Roles Resources, Supervision

  Affiliation National Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China

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• Chen Tan,

  Roles Conceptualization, Funding acquisition, Resources

  Affiliations National Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China, International Research Center for Animal Disease, Ministry of Science and Technology of China, Wuhan, China, Cooperative Innovation Center for Sustainable Pig Production, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China

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• Rui Zhou,

  Roles Conceptualization, Funding acquisition, Project administration, Supervision

  Affiliations National Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China, International Research Center for Animal Disease, Ministry of Science and Technology of China, Wuhan, China, Cooperative Innovation Center for Sustainable Pig Production, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China

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• Qi Huang

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: qhuang@mail.hzau.edu.cn

  Affiliations National Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China, International Research Center for Animal Disease, Ministry of Science and Technology of China, Wuhan, China, Cooperative Innovation Center for Sustainable Pig Production, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China

  https://orcid.org/0000-0002-1600-1169

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