Oligosaccharyltransferase (OST) complex inhibition effectively treats rodent and human prions

• Kathryn S. Beauchemin,

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Biochemistry, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America

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• Judit Kun,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Department of Biochemistry, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America

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• Bradley Groveman,

  Roles Investigation, Methodology, Visualization, Writing – review & editing

  Affiliation Prion Cell Biology Section, Laboratory of Neurological Infections and Immunity, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America

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• Katie Williams,

  Roles Investigation

  Affiliation Prion Cell Biology Section, Laboratory of Neurological Infections and Immunity, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America

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• Francesca Salerno,

  Roles Investigation

  Affiliation Department of Biochemistry, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America

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• Lisa M. Francomacaro,

  Roles Methodology, Resources, Writing – review & editing

  Affiliation Department of Biochemistry, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America

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• Patrick Robison,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Biochemistry, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America

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• Cathryn L. Haigh,

  Roles Methodology, Supervision, Writing – original draft

  Affiliation Prion Cell Biology Section, Laboratory of Neurological Infections and Immunity, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America

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• Surachai Supattapone

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: supattapone@dartmouth.edu

  Affiliations Department of Biochemistry, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America, Department of Medicine, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America

  https://orcid.org/0000-0001-9060-4550

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