Dynamics of lung-infiltrating virus-specific T cells associated with age-dependent SARS-CoV-2 pneumonia severity

• Rise Kurokawa ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  ¶☯ These two authors contributed equally to this study.

  Affiliation Division of Virology and Pathology, Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan

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• Chatherine Silas Mtali ,

  Roles Conceptualization, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  ¶☯ These two authors contributed equally to this study.

  Affiliation Division of Virology and Pathology, Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan

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• Innocent John Daniel,

  Roles Investigation, Writing – review & editing

  Affiliation Division of Virology and Pathology, Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan

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• Thorbjorg Einarsdottir,

  Roles Investigation, Writing – review & editing

  Affiliation Division of Virology and Pathology, Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan

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• Omnia Reda,

  Roles Investigation, Methodology

  Affiliation Division of Genomics and Transcriptomics, Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan

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• Nobuko Irie,

  Roles Resources

  Affiliation Collaboration Unit for Infection, Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan

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• Wajihah Sakhor,

  Roles Investigation

  Affiliation Division of Genomics and Transcriptomics, Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan

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• Koki Niimura,

  Roles Investigation

  Affiliation Division of Genomics and Transcriptomics, Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan

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• Mitsuyoshi Takatori,

  Roles Investigation

  Affiliation Division of Genomics and Transcriptomics, Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan

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• Kenji Sugata,

  Roles Funding acquisition, Investigation, Writing – review & editing

  Affiliation Division of Genomics and Transcriptomics, Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan

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• Chanidapa Adele Tye,

  Roles Investigation

  Affiliation Department of Life Sciences, Imperial College London, London, United Kingdom

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• Yorifumi Satou,

  Roles Conceptualization, Funding acquisition, Writing – original draft, Writing – review & editing

  Affiliation Division of Genomics and Transcriptomics, Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan

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• Masahiro Ono ,

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: m.ono@imperial.ac.uk (MO); nomutaku@kumamoto-u.ac.jp (TN)

  Affiliations Collaboration Unit for Infection, Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan, Department of Life Sciences, Imperial College London, London, United Kingdom

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• Takushi Nomura

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: m.ono@imperial.ac.uk (MO); nomutaku@kumamoto-u.ac.jp (TN)

  Affiliations Division of Virology and Pathology, Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan, AIDS Research Center, National Institute of Infectious Diseases, Japan Institute for Health Security, Tokyo, Japan

  https://orcid.org/0000-0002-4741-4994

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