Trans-complementation of chikungunya virus replicase mutants reveals alphavirus replication complexity and supports antiviral tool development

• Sainan Wang,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Institute of Bioengineering, University of Tartu, Tartu, Estonia

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• Krystyna Naumenko,

  Roles Data curation, Investigation, Methodology

  Affiliations Institute of Bioengineering, University of Tartu, Tartu, Estonia, Zabolotny Institute of Microbiology and Virology of NASU, Kyiv, Ukraine

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• Mandana Mirzajani Sarvandani,

  Roles Investigation

  Current address: Department of Health Sciences, University of Palermo, Palermo, Italy

  Affiliation Institute of Bioengineering, University of Tartu, Tartu, Estonia

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• Laura Sandra Lello,

  Roles Investigation, Methodology

  Affiliation Institute of Bioengineering, University of Tartu, Tartu, Estonia

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• Anna Makhotina,

  Roles Investigation

  Current address: Universitätsklinikum Hamburg-Eppendorf Institut für Medizinische Mikrobiologie, Virologie und Hygiene, Hamburg, Germany

  Affiliation Institute of Bioengineering, University of Tartu, Tartu, Estonia

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• Hanna Carolina Claesson,

  Roles Investigation

  Affiliation Institute of Bioengineering, University of Tartu, Tartu, Estonia

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• Eva Žusinaite,

  Roles Investigation, Methodology

  Affiliation Institute of Bioengineering, University of Tartu, Tartu, Estonia

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• Andres Merits

  Roles Conceptualization, Funding acquisition, Investigation, Project administration, Writing – review & editing

  * E-mail: andres.merits@ut.ee

  Current address: Department of Health Sciences, University of Palermo, Palermo, Italy

  Affiliation Institute of Bioengineering, University of Tartu, Tartu, Estonia

  https://orcid.org/0000-0001-8193-0071

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