A SARS-CoV-2 variant-induced NTD-targeting antibody enhances viral infection via a distinctive binding mode

• Wenting Li ,

  Contributed equally to this work with: Wenting Li, Congcong Liu, Yaning Li, Qi Gui

  Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s Hospital, The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong Province, China

  ⨯
• Congcong Liu ,

  Contributed equally to this work with: Wenting Li, Congcong Liu, Yaning Li, Qi Gui

  Roles Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s Hospital, The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong Province, China

  ⨯
• Yaning Li ,

  Contributed equally to this work with: Wenting Li, Congcong Liu, Yaning Li, Qi Gui

  Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Department of Biochemistry, Key University Laboratory of Metabolism and Health of Guangdong, SUSTech Homeostatic Medicine Institute, School of Medicine, Institute for Biological Electron Microscopy, Southern University of Science and Technology, Shenzhen, Guangdong Province, China, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China

  ⨯
• Qi Gui ,

  Contributed equally to this work with: Wenting Li, Congcong Liu, Yaning Li, Qi Gui

  Roles Data curation, Investigation, Methodology, Validation

  Affiliations Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s Hospital, The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong Province, China, Department of Infectious Diseases, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province, China

  ⨯
• Lin Cheng,

  Roles Investigation, Validation

  Affiliation Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s Hospital, The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong Province, China

  ⨯
• Qing Fan,

  Roles Investigation, Validation

  Affiliation Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s Hospital, The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong Province, China

  ⨯
• Bing Zhou,

  Roles Funding acquisition, Investigation, Validation

  Affiliation Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s Hospital, The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong Province, China

  ⨯
• Haiyan Wang,

  Roles Funding acquisition, Investigation, Validation

  Affiliation Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s Hospital, The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong Province, China

  ⨯
• Xiangyang Ge,

  Roles Investigation, Validation

  Affiliation Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s Hospital, The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong Province, China

  ⨯
• Zheng Zhang ,

  Roles Funding acquisition, Project administration, Supervision

  * E-mail: zhangzheng1975@aliyun.com (ZZ); yanrh@sustech.edu.cn (RY); jubin2013@163.com (BJ)

  Affiliations Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s Hospital, The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong Province, China, Guangdong Key Laboratory for Anti-infection Drug Quality Evaluation, Shenzhen, Guangdong Province, China, Shenzhen Research Center for Communicable Disease Diagnosis and Treatment, Chinese Academy of Medical Sciences, Shenzhen, Guangdong Province, China

  ⨯
• Renhong Yan ,

  Roles Funding acquisition, Project administration, Supervision, Writing – review & editing

  * E-mail: zhangzheng1975@aliyun.com (ZZ); yanrh@sustech.edu.cn (RY); jubin2013@163.com (BJ)

  Affiliation Department of Biochemistry, Key University Laboratory of Metabolism and Health of Guangdong, SUSTech Homeostatic Medicine Institute, School of Medicine, Institute for Biological Electron Microscopy, Southern University of Science and Technology, Shenzhen, Guangdong Province, China

  ⨯
• Bin Ju

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

  * E-mail: zhangzheng1975@aliyun.com (ZZ); yanrh@sustech.edu.cn (RY); jubin2013@163.com (BJ)

  Affiliations Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s Hospital, The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong Province, China, Guangdong Key Laboratory for Anti-infection Drug Quality Evaluation, Shenzhen, Guangdong Province, China

  https://orcid.org/0000-0003-0768-6327

  ⨯