Structural mapping of NTCP distinguishes its dual functionality as a hepatitis B virus receptor and bile acid transporter

• Kayo Matsuzawa,

  Roles Formal analysis, Investigation, Validation, Writing – original draft

  Affiliations Department of Drug Development, National Institute of Infectious Diseases, Japan Institute for Health Security, Tokyo, Japan, Department of Infection Biology, Transborder Medical Research Center, Institute of Medicine, University of Tsukuba, Tsukuba, Japan

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• Toru Ekimoto,

  Roles Data curation, Validation, Formal analysis, Writing – original draft

  Affiliation Computational Life Science Laboratory, Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan

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• Chisa Kobayashi,

  Roles Investigation, Validation, Writing – review & editing

  Affiliation Department of Drug Development, National Institute of Infectious Diseases, Japan Institute for Health Security, Tokyo, Japan

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• Kaho Shionoya,

  Roles Investigation, Validation, Writing – review & editing

  Affiliation Department of Drug Development, National Institute of Infectious Diseases, Japan Institute for Health Security, Tokyo, Japan

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• Junki Mifune,

  Roles Investigation, Validation, Writing – review & editing

  Affiliation Department of Drug Development, National Institute of Infectious Diseases, Japan Institute for Health Security, Tokyo, Japan

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• Takeshi Morita,

  Roles Investigation, Validation, Writing – review & editing

  Affiliation Department of Drug Development, National Institute of Infectious Diseases, Japan Institute for Health Security, Tokyo, Japan

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• Junko S. Takeuchi,

  Roles Formal analysis, Writing – original draft

  Affiliation Department of Academic-Industrial Partnerships Promotion, Center for Clinical Sciences, Japan Institute for Health Security, Tokyo, Japan

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• Sam-Yong Park,

  Roles Funding acquisition, Methodology, Resources, Writing – original draft

  Affiliation Drug Design Laboratory, Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan

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• Mitsunori Ikeguchi,

  Roles Data curation, Formal analysis, Funding acquisition, Writing – original draft

  Affiliations Computational Life Science Laboratory, Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan, HPC- and AI-driven Drug Development Platform Division, Center for Computational Science, RIKEN, Yokohama, Japan

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• Camille Sureau,

  Roles Resources

  Affiliation INSERM U1259, Université de Tours, Tours, France

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• Atsushi Kawaguchi,

  Roles Resources, Writing – review & editing

  Affiliation Department of Infection Biology, Transborder Medical Research Center, Institute of Medicine, University of Tsukuba, Tsukuba, Japan

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• Koichi Watashi

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft

  * E-mail: watashi.k@jihs.go.jp

  Affiliations Department of Drug Development, National Institute of Infectious Diseases, Japan Institute for Health Security, Tokyo, Japan, MIRAI, Japan Science and Technology Agency, Saitama, Japan

  https://orcid.org/0000-0002-4536-9966

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