Colanic acid-mediated phage resistance enhances virulence in high-risk global clone Escherichia coli ST410

Jieying Tu; Jun Yang; Kewei Song; Jinghan Wang; Nuoyan Zhang; Wanyun He; Jinghao Liu; Zhongpeng Cai; Yuman Bai; Luchao Lv; Bingqing Zhu; Pan Tao; Jie Feng; Jian-Hua Liu

doi:10.1371/journal.ppat.1013807

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Open Access

Peer-reviewed

Research Article

Colanic acid-mediated phage resistance enhances virulence in high-risk global clone Escherichia coli ST410

Jieying Tu ,

Contributed equally to this work with: Jieying Tu, Jun Yang

Roles Formal analysis, Investigation, Methodology, Software, Visualization, Writing – original draft

Affiliation State Key Laboratory for Animal Disease Control and Prevention, Key Laboratory of Zoonosis of Ministry of Agricultural and Rural Affairs, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
⨯
Jun Yang ,

Contributed equally to this work with: Jieying Tu, Jun Yang

Roles Investigation, Methodology, Writing – review & editing

Affiliation Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, School of Basic Medical Sciences, Guangdong Pharmaceutical University, Guangzhou, China
⨯
Kewei Song,

Roles Investigation, Methodology

Affiliation State Key Laboratory for Animal Disease Control and Prevention, Key Laboratory of Zoonosis of Ministry of Agricultural and Rural Affairs, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
⨯
Jinghan Wang,

Roles Investigation, Methodology

Affiliation State Key Laboratory for Animal Disease Control and Prevention, Key Laboratory of Zoonosis of Ministry of Agricultural and Rural Affairs, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
⨯
Nuoyan Zhang,

Roles Investigation, Methodology

Affiliation State Key Laboratory for Animal Disease Control and Prevention, Key Laboratory of Zoonosis of Ministry of Agricultural and Rural Affairs, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
⨯
Wanyun He,

Roles Methodology, Visualization

Affiliation State Key Laboratory for Animal Disease Control and Prevention, Key Laboratory of Zoonosis of Ministry of Agricultural and Rural Affairs, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
⨯
Jinghao Liu,

Roles Investigation

Affiliation State Key Laboratory for Animal Disease Control and Prevention, Key Laboratory of Zoonosis of Ministry of Agricultural and Rural Affairs, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
⨯
Zhongpeng Cai,

Roles Software

Affiliation State Key Laboratory for Animal Disease Control and Prevention, Key Laboratory of Zoonosis of Ministry of Agricultural and Rural Affairs, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
⨯
Yuman Bai,

Roles Visualization

Affiliation State Key Laboratory for Animal Disease Control and Prevention, Key Laboratory of Zoonosis of Ministry of Agricultural and Rural Affairs, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
⨯
Luchao Lv,

Roles Software

Affiliation State Key Laboratory for Animal Disease Control and Prevention, Key Laboratory of Zoonosis of Ministry of Agricultural and Rural Affairs, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
⨯
Bingqing Zhu,

Roles Investigation

Affiliation State Key Laboratory for Animal Disease Control and Prevention, Key Laboratory of Zoonosis of Ministry of Agricultural and Rural Affairs, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
⨯
Pan Tao,

Roles Writing – review & editing

Affiliation State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, China
⨯
Jie Feng,

Roles Writing – review & editing

Affiliation State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
⨯
Jian-Hua Liu

Roles Funding acquisition, Supervision, Writing – review & editing

* E-mail: jhliu21@163.com

Affiliation State Key Laboratory for Animal Disease Control and Prevention, Key Laboratory of Zoonosis of Ministry of Agricultural and Rural Affairs, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China

https://orcid.org/0000-0002-3930-7857

⨯

Colanic acid-mediated phage resistance enhances virulence in high-risk global clone Escherichia coli ST410

Jieying Tu,
Jun Yang,
Kewei Song,
Jinghan Wang,
Nuoyan Zhang,
Wanyun He,
Jinghao Liu,
Zhongpeng Cai,
Yuman Bai,
Luchao Lv

Published: December 22, 2025
https://doi.org/10.1371/journal.ppat.1013807

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