Targeting of interaction between BB0323-BB0238 informs new paradigms in Lyme disease therapeutics

Sandhya Bista; Kalvis Brangulis; Bibek Bhattachan; Shelby D. Foor; Michael H. Ronzetti; Sankalp Jain; Jenna Miller; Jothy Lachumy Subramanion; Chrysoula Kitsou; Vipin S. Rana; Ganesha Rai; Alexey V. Zakharov; Anton Simeonov; Bolormaa Baljinnyam; Utpal Pal

doi:10.1371/journal.ppat.1013805

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Open Access

Peer-reviewed

Research Article

Targeting of interaction between BB0323-BB0238 informs new paradigms in Lyme disease therapeutics

Sandhya Bista ,

Contributed equally to this work with: Sandhya Bista, Kalvis Brangulis, Bibek Bhattachan

Roles Formal analysis, Investigation, Methodology, Writing – original draft

Affiliation Department of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America
⨯
Kalvis Brangulis ,

Contributed equally to this work with: Sandhya Bista, Kalvis Brangulis, Bibek Bhattachan

Roles Formal analysis, Investigation, Methodology, Writing – original draft

Affiliations Latvian Biomedical Research and Study Centre, Riga, Latvia, Department of Human Physiology and Biochemistry, Riga Stradins University, Riga, Latvia
⨯
Bibek Bhattachan ,

Contributed equally to this work with: Sandhya Bista, Kalvis Brangulis, Bibek Bhattachan

Roles Formal analysis, Investigation

Affiliation Department of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America
⨯
Shelby D. Foor,

Roles Formal analysis, Investigation

Affiliation Department of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America
⨯
Michael H. Ronzetti,

Roles Formal analysis, Investigation, Resources

Affiliations Department of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, United States of America
⨯
Sankalp Jain,

Roles Formal analysis

Affiliation National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, United States of America
⨯
Jenna Miller,

Roles Investigation

Affiliation National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, United States of America
⨯
Jothy Lachumy Subramanion,

Roles Formal analysis, Investigation

Affiliation Department of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America
⨯
Chrysoula Kitsou,

Roles Formal analysis, Investigation

Affiliation Department of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America
⨯
Vipin S. Rana,

Roles Formal analysis, Resources

Affiliation Department of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America
⨯
Ganesha Rai,

Roles Formal analysis, Resources

Affiliation National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, United States of America
⨯
Alexey V. Zakharov,

Roles Formal analysis

Affiliation National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, United States of America
⨯
Anton Simeonov,

Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Supervision, Writing – review & editing

Affiliation National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, United States of America
⨯
Bolormaa Baljinnyam ,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

* E-mail: baljinnb@mail.nih.gov (BB); upal@umd.edu (UP)

Affiliation National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, United States of America
⨯
Utpal Pal

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

* E-mail: baljinnb@mail.nih.gov (BB); upal@umd.edu (UP)

Affiliations Department of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America, Virginia-Maryland College of Veterinary Medicine, College Park, Maryland, United States of America

https://orcid.org/0000-0002-7504-4628

⨯

Targeting of interaction between BB0323-BB0238 informs new paradigms in Lyme disease therapeutics

Sandhya Bista,
Kalvis Brangulis,
Bibek Bhattachan,
Shelby D. Foor,
Michael H. Ronzetti,
Sankalp Jain,
Jenna Miller,
Jothy Lachumy Subramanion,
Chrysoula Kitsou,
Vipin S. Rana

Published: January 2, 2026
https://doi.org/10.1371/journal.ppat.1013805

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