A conserved enzymatic toolkit targeting host cell metabolism is associated with Cryptococcus neoformans intracellular survival in protozoal and mammalian phagocytic cells

Quigly Dragotakes; Ella Jacobs; Gracen Gerbig; Seth Greengo; Anne Jedlicka; Amanda Dziedzic; Arturo Casadevall

doi:10.1371/journal.ppat.1013787

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Peer-reviewed

Research Article

A conserved enzymatic toolkit targeting host cell metabolism is associated with Cryptococcus neoformans intracellular survival in protozoal and mammalian phagocytic cells

Quigly Dragotakes ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

* E-mail: qdragot@jhu.edu

Affiliation Department of Microbiology and Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America

https://orcid.org/0000-0003-4068-5828

⨯
Ella Jacobs,

Roles Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Microbiology and Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
⨯
Gracen Gerbig,

Roles Investigation, Methodology, Writing – review & editing

Affiliation Department of Microbiology and Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
⨯
Seth Greengo,

Roles Investigation, Methodology, Writing – review & editing

Affiliation Department of Microbiology and Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
⨯
Anne Jedlicka,

Roles Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Microbiology and Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
⨯
Amanda Dziedzic,

Roles Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Microbiology and Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
⨯
Arturo Casadevall

Roles Funding acquisition, Writing – original draft, Writing – review & editing

Affiliation Department of Microbiology and Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
⨯

A conserved enzymatic toolkit targeting host cell metabolism is associated with Cryptococcus neoformans intracellular survival in protozoal and mammalian phagocytic cells

Quigly Dragotakes,
Ella Jacobs,
Gracen Gerbig,
Seth Greengo,
Anne Jedlicka,
Amanda Dziedzic,
Arturo Casadevall

Published: December 26, 2025
https://doi.org/10.1371/journal.ppat.1013787

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