Cyclic AMP compartmentalization drives signal specificity to control vector colonization and mammalian host infection by American trypanosomes

Milad Ahmed; Joshua Carlson; Asima Das; Syeda Farjana Hoque; Joshua B. Benoit; Miguel A. Chiurillo; Noelia Lander

doi:10.1371/journal.ppat.1013784

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Open Access

Peer-reviewed

Research Article

Cyclic AMP compartmentalization drives signal specificity to control vector colonization and mammalian host infection by American trypanosomes

Milad Ahmed,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio, United States of America
⨯
Joshua Carlson,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology

Affiliation Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio, United States of America
⨯
Asima Das,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology

Affiliation Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio, United States of America
⨯
Syeda Farjana Hoque,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology

Affiliation Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio, United States of America
⨯
Joshua B. Benoit,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Writing – review & editing

Affiliation Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio, United States of America
⨯
Miguel A. Chiurillo,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Validation, Visualization, Writing – review & editing

Affiliation Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio, United States of America
⨯
Noelia Lander

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

* E-mail: landernm@ucmail.uc.edu

Affiliation Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio, United States of America

https://orcid.org/0000-0003-2178-381X

⨯

Cyclic AMP compartmentalization drives signal specificity to control vector colonization and mammalian host infection by American trypanosomes

Milad Ahmed,
Joshua Carlson,
Asima Das,
Syeda Farjana Hoque,
Joshua B. Benoit,
Miguel A. Chiurillo,
Noelia Lander

Published: June 29, 2026
https://doi.org/10.1371/journal.ppat.1013784
See the preprint

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cAMP signaling cascade
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