Rare metabolic gene essentiality is a determinant of microniche adaptation in Eschherichia coli

• Omid Ardalani,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby, Denmark

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• Patrick V. Phaneuf,

  Roles Project administration, Resources, Writing – review & editing

  Affiliation Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby, Denmark

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• Jayanth Krishnan,

  Roles Data curation, Investigation, Validation, Writing – review & editing

  Affiliation Department of Bioengineering, University of California, San Diego, La Jolla, California, United States of America

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• Siddharth M. Chauhan,

  Roles Data curation, Writing – review & editing

  Affiliation Department of Bioengineering, University of California, San Diego, La Jolla, California, United States of America

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• David Pride,

  Roles Investigation, Resources, Writing – review & editing

  Affiliation Department of Pathology, University of California, San Diego, La Jolla, California, United States of America

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• Daniel C. Zielinski,

  Roles Methodology, Writing – review & editing

  Affiliation Department of Bioengineering, University of California, San Diego, La Jolla, California, United States of America

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• Jonathan M. Monk,

  Roles Methodology, Writing – review & editing

  Affiliation Department of Bioengineering, University of California, San Diego, La Jolla, California, United States of America

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• Lars K. Nielsen,

  Roles Conceptualization, Writing – review & editing

  Affiliations Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby, Denmark, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Queensland, Australia

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• Bernhard O. Palsson

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: bpalsson@ucsd.edu

  Affiliations Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby, Denmark, Department of Bioengineering, University of California, San Diego, La Jolla, California, United States of America, Bioinformatics and Systems Biology Program, University of California, San Diego, La Jolla, California, United States of America, Department of Pediatrics, University of California, San Diego, La Jolla, California, United States of America, Center for Microbiome Innovation, University of California, San Diego, La Jolla, California, United States of America

  https://orcid.org/0000-0003-2357-6785

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