Monoclonal neutralizing antibodies elicited by infection with Kaposi sarcoma-associated herpesvirus reveal critical sites of vulnerability on gH/gL

Yu-Hsin Wan; Sara Pernikoff; Nicholas T. Aldridge; Kevin Lang; Holly M. Dudley; Samuel C. Scharffenberger; Gargi Kher; Warren Phipps; Marie Pancera; Jim Boonyaratanakornkit; Andrew T. McGuire

doi:10.1371/journal.ppat.1013772

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Open Access

Peer-reviewed

Research Article

Monoclonal neutralizing antibodies elicited by infection with Kaposi sarcoma-associated herpesvirus reveal critical sites of vulnerability on gH/gL

Yu-Hsin Wan,

Roles Formal analysis, Investigation, Visualization, Writing – review & editing

Affiliation Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America
⨯
Sara Pernikoff,

Roles Investigation, Visualization, Writing – review & editing

Affiliation Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America
⨯
Nicholas T. Aldridge,

Roles Formal analysis, Investigation, Visualization, Writing – review & editing

Affiliation Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America
⨯
Kevin Lang,

Roles Formal analysis, Investigation, Visualization, Writing – review & editing

Affiliation Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America
⨯
Holly M. Dudley,

Roles Formal analysis, Investigation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America
⨯
Samuel C. Scharffenberger,

Roles Investigation, Visualization, Writing – review & editing

Affiliation Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America
⨯
Gargi Kher,

Roles Formal analysis, Investigation, Visualization, Writing – review & editing

Affiliation Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America
⨯
Warren Phipps,

Roles Conceptualization, Funding acquisition, Resources, Writing – review & editing

Affiliations Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America, Department of Medicine, University of Washington, Seattle, Washington, United States of America
⨯
Marie Pancera,

Roles Conceptualization, Resources, Writing – review & editing

Affiliation Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America
⨯
Jim Boonyaratanakornkit,

Roles Conceptualization, Funding acquisition, Resources, Writing – review & editing

Affiliations Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America, Department of Medicine, University of Washington, Seattle, Washington, United States of America
⨯
Andrew T. McGuire

Roles Conceptualization, Formal analysis, Funding acquisition, Resources, Writing – original draft, Writing – review & editing

* E-mail: amcguire@fredhutch.org

Affiliations Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America, Department of Global Health, University of Washington, Seattle, Washington, United States of America, Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, United States of America

https://orcid.org/0000-0003-1841-6859

⨯

Monoclonal neutralizing antibodies elicited by infection with Kaposi sarcoma-associated herpesvirus reveal critical sites of vulnerability on gH/gL

Yu-Hsin Wan,
Sara Pernikoff,
Nicholas T. Aldridge,
Kevin Lang,
Holly M. Dudley,
Samuel C. Scharffenberger,
Gargi Kher,
Warren Phipps,
Marie Pancera,
Jim Boonyaratanakornkit

Published: January 7, 2026
https://doi.org/10.1371/journal.ppat.1013772

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