Acoziborole resistance associated mutations in Trypanosoma brucei CPSF3

Melanie Ridgway; Markéta Novotná; Cesar Mendoza-Martinez; Michele Tinti; Simone Altmann; Graeme Sloan; David Horn

doi:10.1371/journal.ppat.1013764

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Open Access

Peer-reviewed

Research Article

Acoziborole resistance associated mutations in Trypanosoma brucei CPSF3

Melanie Ridgway,

Roles Conceptualization, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation Faculty of Life Sciences, University of Dundee, Dundee, United Kingdom
⨯
Markéta Novotná,

Roles Investigation, Writing – review & editing

Affiliation Faculty of Life Sciences, University of Dundee, Dundee, United Kingdom
⨯
Cesar Mendoza-Martinez,

Roles Formal analysis, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Faculty of Life Sciences, University of Dundee, Dundee, United Kingdom, Drug Discovery Unit, Faculty of Life Sciences, University of Dundee, Dundee, United Kingdom
⨯
Michele Tinti,

Roles Data curation, Writing – review & editing

Affiliation Faculty of Life Sciences, University of Dundee, Dundee, United Kingdom
⨯
Simone Altmann,

Roles Investigation, Writing – review & editing

Affiliation Faculty of Life Sciences, University of Dundee, Dundee, United Kingdom
⨯
Graeme Sloan,

Roles Supervision

Affiliations Faculty of Life Sciences, University of Dundee, Dundee, United Kingdom, Drug Discovery Unit, Faculty of Life Sciences, University of Dundee, Dundee, United Kingdom
⨯
David Horn

Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: d.horn@dundee.ac.uk

Affiliation Faculty of Life Sciences, University of Dundee, Dundee, United Kingdom

https://orcid.org/0000-0001-5173-9284

⨯

Acoziborole resistance associated mutations in Trypanosoma brucei CPSF3

Melanie Ridgway,
Markéta Novotná,
Cesar Mendoza-Martinez,
Michele Tinti,
Simone Altmann,
Graeme Sloan,
David Horn

Published: March 3, 2026
https://doi.org/10.1371/journal.ppat.1013764

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Trypanosoma brucei gambiense
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Library screening
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Transfection
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