ARCN1 suppresses innate immune responses against respiratory syncytial virus by promoting STUB1-mediated IKKε degradation

Jiamin Cai; Yunfei Ye; Zhengrong Chen; Fei Xu; Xiaoping Li; Mengyun Wu; Ji Zhou; Yu Shao; Peijie Zhu; Jing Zhao; Jingjing Hu; Yufeng Wang; Cancheng Li; Xiaoyu Tian; Beibei Huang; Tian Xia; Wenjun Wang; Chuangli Hao; Yi Yang; Jinping Zhang

doi:10.1371/journal.ppat.1013751

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Open Access

Peer-reviewed

Research Article

ARCN1 suppresses innate immune responses against respiratory syncytial virus by promoting STUB1-mediated IKKε degradation

Jiamin Cai ,

Contributed equally to this work with: Jiamin Cai, Yunfei Ye, Zhengrong Chen, Fei Xu

Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Validation, Writing – original draft, Writing – review & editing

Affiliation The Fourth Affiliated Hospital, Institutes of Biology and Medical Sciences, Suzhou Medical College, Soochow University, Suzhou, People’s Republic of China
⨯
Yunfei Ye ,

Contributed equally to this work with: Jiamin Cai, Yunfei Ye, Zhengrong Chen, Fei Xu

Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Validation

Affiliation The Fourth Affiliated Hospital, Institutes of Biology and Medical Sciences, Suzhou Medical College, Soochow University, Suzhou, People’s Republic of China
⨯
Zhengrong Chen ,

Contributed equally to this work with: Jiamin Cai, Yunfei Ye, Zhengrong Chen, Fei Xu

Roles Funding acquisition, Investigation

Affiliation Department of Respiratory Medicine, Children’s Hospital of Soochow University, Suzhou, China
⨯
Fei Xu ,

Contributed equally to this work with: Jiamin Cai, Yunfei Ye, Zhengrong Chen, Fei Xu

Roles Formal analysis, Funding acquisition, Investigation, Resources

Affiliation The Fourth Affiliated Hospital, Institutes of Biology and Medical Sciences, Suzhou Medical College, Soochow University, Suzhou, People’s Republic of China
⨯
Xiaoping Li,

Roles Methodology, Resources

Affiliation Department of Clinical Laboratory, Soochow University Affiliated No 1 People’s Hospital: First Affiliated Hospital of Soochow University, Suzhou, China
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Mengyun Wu,

Roles Methodology, Resources

Affiliation The Fourth Affiliated Hospital, Institutes of Biology and Medical Sciences, Suzhou Medical College, Soochow University, Suzhou, People’s Republic of China
⨯
Ji Zhou,

Roles Methodology, Resources

Affiliation The Fourth Affiliated Hospital, Institutes of Biology and Medical Sciences, Suzhou Medical College, Soochow University, Suzhou, People’s Republic of China
⨯
Yu Shao,

Roles Resources

Affiliation The Fourth Affiliated Hospital, Institutes of Biology and Medical Sciences, Suzhou Medical College, Soochow University, Suzhou, People’s Republic of China
⨯
Peijie Zhu,

Roles Resources

Affiliation The Fourth Affiliated Hospital, Institutes of Biology and Medical Sciences, Suzhou Medical College, Soochow University, Suzhou, People’s Republic of China
⨯
Jing Zhao,

Roles Resources

Affiliation The Fourth Affiliated Hospital, Institutes of Biology and Medical Sciences, Suzhou Medical College, Soochow University, Suzhou, People’s Republic of China
⨯
Jingjing Hu,

Roles Resources

Affiliation The Fourth Affiliated Hospital, Institutes of Biology and Medical Sciences, Suzhou Medical College, Soochow University, Suzhou, People’s Republic of China
⨯
Yufeng Wang,

Roles Resources

Affiliation Department of Respiratory Medicine, Children’s Hospital of Soochow University, Suzhou, China
⨯
Cancheng Li,

Roles Resources

Affiliation The Fourth Affiliated Hospital, Institutes of Biology and Medical Sciences, Suzhou Medical College, Soochow University, Suzhou, People’s Republic of China
⨯
Xiaoyu Tian,

Roles Resources

Affiliation The Fourth Affiliated Hospital, Institutes of Biology and Medical Sciences, Suzhou Medical College, Soochow University, Suzhou, People’s Republic of China
⨯
Beibei Huang,

Roles Resources

Affiliation The Fourth Affiliated Hospital, Institutes of Biology and Medical Sciences, Suzhou Medical College, Soochow University, Suzhou, People’s Republic of China
⨯
Tian Xia,

Roles Resources

Affiliation The Fourth Affiliated Hospital, Institutes of Biology and Medical Sciences, Suzhou Medical College, Soochow University, Suzhou, People’s Republic of China
⨯
Wenjun Wang,

Roles Resources

Affiliation The Fourth Affiliated Hospital, Institutes of Biology and Medical Sciences, Suzhou Medical College, Soochow University, Suzhou, People’s Republic of China
⨯
Chuangli Hao,

Roles Funding acquisition

Affiliation Department of Respiratory Medicine, Children’s Hospital of Soochow University, Suzhou, China
⨯
Yi Yang ,

Roles Writing – original draft, Writing – review & editing

* E-mail: j_pzhang@suda.edu.cn (JZ); yangyi87@suda.edu.cn (YY)

Affiliation The Fourth Affiliated Hospital, Institutes of Biology and Medical Sciences, Suzhou Medical College, Soochow University, Suzhou, People’s Republic of China
⨯
[ ... ],
Jinping Zhang

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: j_pzhang@suda.edu.cn (JZ); yangyi87@suda.edu.cn (YY)

Affiliation The Fourth Affiliated Hospital, Institutes of Biology and Medical Sciences, Suzhou Medical College, Soochow University, Suzhou, People’s Republic of China

https://orcid.org/0000-0001-5537-5131

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ARCN1 suppresses innate immune responses against respiratory syncytial virus by promoting STUB1-mediated IKKε degradation

Jiamin Cai,
Yunfei Ye,
Zhengrong Chen,
Fei Xu,
Xiaoping Li,
Mengyun Wu,
Ji Zhou,
Yu Shao,
Peijie Zhu,
Jing Zhao

Published: December 4, 2025
https://doi.org/10.1371/journal.ppat.1013751

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