Bimodal expression of Type 3 Secretion System 2 enables cooperative virulence among intracellular Salmonella Typhimurium

Milada Pospíšilová; Alona Dreus; Paulina Matheova; Jana Schmidtova; Barbora Pravdova; Michaela Blazikova; Martin Capek; Ondrej Cerny

doi:10.1371/journal.ppat.1013728

Loading metrics

Open Access

Peer-reviewed

Research Article

Bimodal expression of Type 3 Secretion System 2 enables cooperative virulence among intracellular Salmonella Typhimurium

Milada Pospíšilová,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Visualization, Writing – original draft

Affiliations Laboratory of Bacterial Virulence, Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic, Faculty of Science, Charles University in Prague, Prague, Czech Republic
⨯
Alona Dreus,

Roles Formal analysis, Methodology, Visualization

Affiliations Laboratory of Bacterial Virulence, Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic, Faculty of Science, Charles University in Prague, Prague, Czech Republic
⨯
Paulina Matheova,

Roles Formal analysis, Investigation, Methodology, Visualization

Affiliations Laboratory of Bacterial Virulence, Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic, Faculty of Science, Charles University in Prague, Prague, Czech Republic
⨯
Jana Schmidtova,

Roles Investigation

Affiliation Laboratory of Bacterial Virulence, Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic
⨯
Barbora Pravdova,

Roles Investigation

Affiliation Laboratory of Bacterial Virulence, Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic
⨯
Michaela Blazikova,

Roles Formal analysis, Visualization

Affiliation Light Microscopy, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic
⨯
Martin Capek,

Roles Formal analysis, Visualization

Affiliations Light Microscopy, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic, Laboratory of Biomathematics, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic
⨯
Ondrej Cerny

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft

* E-mail: ondrej.cerny@biomed.cas.cz

Affiliation Laboratory of Bacterial Virulence, Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic

https://orcid.org/0000-0001-9570-5449

⨯

Bimodal expression of Type 3 Secretion System 2 enables cooperative virulence among intracellular Salmonella Typhimurium

Milada Pospíšilová,
Alona Dreus,
Paulina Matheova,
Jana Schmidtova,
Barbora Pravdova,
Michaela Blazikova,
Martin Capek,
Ondrej Cerny

Published: December 1, 2025
https://doi.org/10.1371/journal.ppat.1013728

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Salmonella
Is the Subject Area "Salmonella" applicable to this article?

Thanks for your feedback.
Macrophages
Is the Subject Area "Macrophages" applicable to this article?

Thanks for your feedback.
Salmonellosis
Is the Subject Area "Salmonellosis" applicable to this article?

Thanks for your feedback.
Host cells
Is the Subject Area "Host cells" applicable to this article?

Thanks for your feedback.
Flow cytometry
Is the Subject Area "Flow cytometry" applicable to this article?

Thanks for your feedback.
Bacteria
Is the Subject Area "Bacteria" applicable to this article?

Thanks for your feedback.
Intracellular pathogens
Is the Subject Area "Intracellular pathogens" applicable to this article?

Thanks for your feedback.
Lysis (medicine)
Is the Subject Area "Lysis (medicine)" applicable to this article?

Thanks for your feedback.