Structural determinants of SlpA-mediated phage recognition in Clostridioides difficile

Alexia L.M. Royer; Émeline Dion; Andrew A. Umansky; Mariano Avino; Olga Soutourina; Louis-Charles Fortier

doi:10.1371/journal.ppat.1013724

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Open Access

Peer-reviewed

Research Article

Structural determinants of SlpA-mediated phage recognition in Clostridioides difficile

Alexia L.M. Royer,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Department of Microbiology and Infectious Diseases, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Québec, Canada, Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, France
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Émeline Dion,

Roles Investigation

Affiliation Department of Microbiology and Infectious Diseases, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Québec, Canada
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Andrew A. Umansky,

Roles Investigation, Writing – original draft, Writing – review & editing

Affiliation Department of Microbiology and Infectious Diseases, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Québec, Canada
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Mariano Avino,

Roles Investigation, Software, Writing – original draft, Writing – review & editing

Affiliation Bio-informatic Platform, Department of Biochemistry and Functional Genomics, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Québec, Canada
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Olga Soutourina,

Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

Affiliation Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, France
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Louis-Charles Fortier

Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft

* E-mail: Louis-Charles.Fortier@USherbrooke.ca

Affiliation Department of Microbiology and Infectious Diseases, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Québec, Canada

https://orcid.org/0000-0003-1950-763X

⨯

Structural determinants of SlpA-mediated phage recognition in Clostridioides difficile

Alexia L.M. Royer,
Émeline Dion,
Andrew A. Umansky,
Mariano Avino,
Olga Soutourina,
Louis-Charles Fortier

Published: November 26, 2025
https://doi.org/10.1371/journal.ppat.1013724

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Bacteriophages
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Adsorption
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Lysis (medicine)
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Protein interactions
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Protein domains
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Polymerase chain reaction
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Protein structure prediction
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Point mutation
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