The assembly of stress granules during foot-and-mouth disease virus infection is uncoupled from activation of cellular intrinsic antiviral signalling

Mariana Marques; Yui Xi Wong; Zhaozhi Sun; Amina Yasmin; J. Paul Taylor; Alessia Ruggieri; Tobias J. Tuthill; Nicolas Locker

doi:10.1371/journal.ppat.1013722

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Open Access

Peer-reviewed

Research Article

The assembly of stress granules during foot-and-mouth disease virus infection is uncoupled from activation of cellular intrinsic antiviral signalling

Mariana Marques,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft

Affiliation The Pirbright Institute, Pirbright, Surrey, United Kingdom

https://orcid.org/0000-0003-1284-334X

⨯
Yui Xi Wong,

Roles Data curation, Investigation

Affiliations The Pirbright Institute, Pirbright, Surrey, United Kingdom, The University of Manchester, Manchester, United Kingdom
⨯
Zhaozhi Sun,

Roles Investigation, Methodology

Affiliation Heidelberg University, Medical Faculty Heidelberg, Department of Infectious Diseases, Molecular Virology, Centre for Integrative Infectious Disease Research, Heidelberg, Germany
⨯
Amina Yasmin,

Roles Methodology

Affiliation The Pirbright Institute, Pirbright, Surrey, United Kingdom
⨯
J. Paul Taylor,

Roles Resources, Writing – review & editing

Affiliation Department of Cell and Molecular Biology, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
⨯
Alessia Ruggieri,

Roles Funding acquisition, Project administration, Supervision, Writing – review & editing

Affiliation Heidelberg University, Medical Faculty Heidelberg, Department of Infectious Diseases, Molecular Virology, Centre for Integrative Infectious Disease Research, Heidelberg, Germany
⨯
Tobias J. Tuthill,

Roles Resources, Supervision, Writing – review & editing

Affiliation The Pirbright Institute, Pirbright, Surrey, United Kingdom
⨯
Nicolas Locker

Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

* E-mail: nicolas.locker@pirbright.ac.uk

Affiliation The Pirbright Institute, Pirbright, Surrey, United Kingdom

https://orcid.org/0000-0002-0053-2897

⨯

The assembly of stress granules during foot-and-mouth disease virus infection is uncoupled from activation of cellular intrinsic antiviral signalling

Mariana Marques,
Yui Xi Wong,
Zhaozhi Sun,
Amina Yasmin,
J. Paul Taylor,
Alessia Ruggieri,
Tobias J. Tuthill,
Nicolas Locker

Published: June 11, 2026
https://doi.org/10.1371/journal.ppat.1013722

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Viral replication
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Transfection
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Immunofluorescence
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Phosphorylation
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Cell signaling
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DAPI staining
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Foot and mouth disease
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Nuclear staining
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