Antibiotic-resistance mutations in penicillin-binding protein 2 from the ceftriaxone-resistant Neisseria gonorrhoeae strain H041 strike a delicate balance between increasing resistance and maintaining transpeptidase activity

• Marissa M. Bivins ,

  Contributed equally to this work with: Marissa M. Bivins, Joshua Tomberg

  Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Writing – original draft, Writing – review & editing

  Affiliation Department of Pharmacology, University of North Carolina – Chapel Hill, Chapel Hill, North Carolina, United States of America

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• Joshua Tomberg ,

  Contributed equally to this work with: Marissa M. Bivins, Joshua Tomberg

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Department of Pharmacology, University of North Carolina – Chapel Hill, Chapel Hill, North Carolina, United States of America

  ⨯
• Madeleine Bagshaw,

  Roles Investigation, Methodology

  Current address: Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee, United States of America

  Affiliation Department of Biology, University of North Carolina – Chapel Hill, Chapel Hill, North Carolina, United States of America

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• Avinash Singh,

  Roles Formal analysis, Investigation, Methodology

  Current address: Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, United States of America

  Affiliation Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, United States of America

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• Sandeepchowdary Bala,

  Roles Formal analysis, Visualization

  Affiliation Department of Biochemistry & Molecular Biology, University of South Alabama, Mobile, Alabama, United States of America

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• Christopher Davies ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Resources, Supervision, Visualization, Writing – review & editing

  * E-mail: cdavies@southalabama.edu (CD); nicholas@med.unc.edu (RAN)

  Affiliation Department of Biochemistry & Molecular Biology, University of South Alabama, Mobile, Alabama, United States of America

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• Robert A. Nicholas

  Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Resources, Supervision, Visualization, Writing – review & editing

  * E-mail: cdavies@southalabama.edu (CD); nicholas@med.unc.edu (RAN)

  Affiliations Department of Pharmacology, University of North Carolina – Chapel Hill, Chapel Hill, North Carolina, United States of America, Department of Microbiology and Immunology, University of North Carolina – Chapel Hill, Chapel Hill, North Carolina, United States of America

  https://orcid.org/0000-0003-2507-8974

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