Antiviral and immune modulatory activities of STING agonists in a mouse model of persistent hepatitis B virus infection

Ya Wang; Shuo Wu; Xingqiong Li; Lijun Qiao; Huiqiang Wang; Ge Yang; Haiyan Yan; Kun Wang; Jian-Dong Jiang; Yuhuan Li

doi:10.1371/journal.ppat.1013709

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Open Access

Peer-reviewed

Research Article

Antiviral and immune modulatory activities of STING agonists in a mouse model of persistent hepatitis B virus infection

Ya Wang ,

Contributed equally to this work with: Ya Wang, Shuo Wu

Roles Data curation, Formal analysis, Methodology, Validation, Writing – original draft

Affiliation CAMS Key Laboratory of Antiviral Drug Research, Beijing Key Laboratory of Technology and Application for Anti-Infective New Drugs Research and Development, NHC Key Laboratory of Biotechnology for Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Shuo Wu ,

Contributed equally to this work with: Ya Wang, Shuo Wu

Roles Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

* E-mail: wushuoimb@126.com (SW); yuhuanlibj@126.com (YL)

Affiliations CAMS Key Laboratory of Antiviral Drug Research, Beijing Key Laboratory of Technology and Application for Anti-Infective New Drugs Research and Development, NHC Key Laboratory of Biotechnology for Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Xingqiong Li,

Roles Data curation, Formal analysis, Investigation, Methodology

Affiliation CAMS Key Laboratory of Antiviral Drug Research, Beijing Key Laboratory of Technology and Application for Anti-Infective New Drugs Research and Development, NHC Key Laboratory of Biotechnology for Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Lijun Qiao,

Roles Data curation, Formal analysis, Methodology

Affiliation CAMS Key Laboratory of Antiviral Drug Research, Beijing Key Laboratory of Technology and Application for Anti-Infective New Drugs Research and Development, NHC Key Laboratory of Biotechnology for Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Huiqiang Wang,

Roles Data curation, Methodology

Affiliation CAMS Key Laboratory of Antiviral Drug Research, Beijing Key Laboratory of Technology and Application for Anti-Infective New Drugs Research and Development, NHC Key Laboratory of Biotechnology for Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Ge Yang,

Roles Data curation, Methodology

Affiliation CAMS Key Laboratory of Antiviral Drug Research, Beijing Key Laboratory of Technology and Application for Anti-Infective New Drugs Research and Development, NHC Key Laboratory of Biotechnology for Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Haiyan Yan,

Roles Formal analysis, Methodology

Affiliation CAMS Key Laboratory of Antiviral Drug Research, Beijing Key Laboratory of Technology and Application for Anti-Infective New Drugs Research and Development, NHC Key Laboratory of Biotechnology for Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Kun Wang,

Roles Data curation, Methodology

Affiliation CAMS Key Laboratory of Antiviral Drug Research, Beijing Key Laboratory of Technology and Application for Anti-Infective New Drugs Research and Development, NHC Key Laboratory of Biotechnology for Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Jian-Dong Jiang,

Roles Resources, Writing – review & editing

Affiliations CAMS Key Laboratory of Antiviral Drug Research, Beijing Key Laboratory of Technology and Application for Anti-Infective New Drugs Research and Development, NHC Key Laboratory of Biotechnology for Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Yuhuan Li

Roles Conceptualization, Funding acquisition, Investigation, Project administration, Resources, Writing – review & editing

* E-mail: wushuoimb@126.com (SW); yuhuanlibj@126.com (YL)

Affiliations CAMS Key Laboratory of Antiviral Drug Research, Beijing Key Laboratory of Technology and Application for Anti-Infective New Drugs Research and Development, NHC Key Laboratory of Biotechnology for Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

https://orcid.org/0000-0003-3725-3258

⨯

Antiviral and immune modulatory activities of STING agonists in a mouse model of persistent hepatitis B virus infection

Ya Wang,
Shuo Wu,
Xingqiong Li,
Lijun Qiao,
Huiqiang Wang,
Ge Yang,
Haiyan Yan,
Kun Wang,
Jian-Dong Jiang,
Yuhuan Li

Published: December 9, 2025
https://doi.org/10.1371/journal.ppat.1013709

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