Filovirus infection disrupts epithelial barrier function and ion transport in human iPSC-derived gut organoids

• Elizabeth Y. Flores,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Center for Regenerative Medicine (CReM), Boston University Chobanian & Avedisian School of Medicine and Boston Medical Center, Boston, Massachusetts, United States of America, National Emerging Infectious Diseases Laboratories (NEIDL), Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, United States of America

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• Adam J. Hume ,

  Contributed equally to this work with: Adam J. Hume, Judith Olejnik, Aditya Mithal

  Roles Investigation, Methodology, Supervision, Writing – review & editing

  Affiliations National Emerging Infectious Diseases Laboratories (NEIDL), Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, United States of America, Department of Virology, Immunology & Microbiology, Boston University Chobanian & Avedisian School of Medicine, Boston Massachusetts, United States of America

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• Judith Olejnik ,

  Contributed equally to this work with: Adam J. Hume, Judith Olejnik, Aditya Mithal

  Roles Data curation, Investigation, Methodology, Supervision, Writing – review & editing

  Affiliations National Emerging Infectious Diseases Laboratories (NEIDL), Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, United States of America, Department of Virology, Immunology & Microbiology, Boston University Chobanian & Avedisian School of Medicine, Boston Massachusetts, United States of America

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• Aditya Mithal ,

  Contributed equally to this work with: Adam J. Hume, Judith Olejnik, Aditya Mithal

  Roles Methodology

  Affiliations Center for Regenerative Medicine (CReM), Boston University Chobanian & Avedisian School of Medicine and Boston Medical Center, Boston, Massachusetts, United States of America, Current address: Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America

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• Andrew D’Amico,

  Roles Methodology

  Affiliation Center for Regenerative Medicine (CReM), Boston University Chobanian & Avedisian School of Medicine and Boston Medical Center, Boston, Massachusetts, United States of America

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• MengWei Yang,

  Roles Methodology

  Affiliation Center for Regenerative Medicine (CReM), Boston University Chobanian & Avedisian School of Medicine and Boston Medical Center, Boston, Massachusetts, United States of America

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• Pushpinder Bawa,

  Roles Data curation, Formal analysis, Validation

  Affiliation Center for Regenerative Medicine (CReM), Boston University Chobanian & Avedisian School of Medicine and Boston Medical Center, Boston, Massachusetts, United States of America

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• Feiya Wang,

  Roles Data curation, Formal analysis, Validation

  Affiliation Center for Regenerative Medicine (CReM), Boston University Chobanian & Avedisian School of Medicine and Boston Medical Center, Boston, Massachusetts, United States of America

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• Aoife K. O’Connell,

  Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – review & editing

  Affiliation National Emerging Infectious Diseases Laboratories (NEIDL), Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, United States of America

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• Anna Tseng,

  Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – review & editing

  Affiliations National Emerging Infectious Diseases Laboratories (NEIDL), Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, United States of America, Department of Virology, Immunology & Microbiology, Boston University Chobanian & Avedisian School of Medicine, Boston Massachusetts, United States of America, Department of Pathology and Laboratory Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, United States of America

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• Nicholas A. Crossland,

  Roles Data curation, Formal analysis, Investigation, Methodology, Supervision, Visualization, Writing – review & editing

  Affiliations National Emerging Infectious Diseases Laboratories (NEIDL), Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, United States of America, Department of Virology, Immunology & Microbiology, Boston University Chobanian & Avedisian School of Medicine, Boston Massachusetts, United States of America, Department of Pathology and Laboratory Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, United States of America

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• Gustavo Mostoslavsky ,

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Visualization, Writing – review & editing

  * E-mail: muehlber@bu.edu (EM); gmostosl@bu.edu (GM)

  Affiliations Center for Regenerative Medicine (CReM), Boston University Chobanian & Avedisian School of Medicine and Boston Medical Center, Boston, Massachusetts, United States of America, Department of Medicine, Section of Gastroenterology; Department of Virology, Immunology, and Microbiology. Boston University Chobanian & Avedisian School of Medicine, Boston Massachusetts, United States of America

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• Elke Mühlberger

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Visualization, Writing – review & editing

  * E-mail: muehlber@bu.edu (EM); gmostosl@bu.edu (GM)

  Affiliations National Emerging Infectious Diseases Laboratories (NEIDL), Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, United States of America, Department of Virology, Immunology & Microbiology, Boston University Chobanian & Avedisian School of Medicine, Boston Massachusetts, United States of America

  https://orcid.org/0000-0003-3547-9376

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