The B169L protein of African swine fever virus functions as a viroporin that activates the calcium-mediated inflammasome

• Jiaqi Li ,

  Contributed equally to this work with: Jiaqi Li, Qiguang Li

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

  Affiliation State Key Laboratory of Animal Disease Prevention and Control, National African Swine Fever Para-Reference Laboratory, National High-Containment Facilities for Animal Diseases Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, Heilongjiang, China

  ⨯
• Qiguang Li ,

  Contributed equally to this work with: Jiaqi Li, Qiguang Li

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

  Affiliation CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

  ⨯
• Yanjin Wang,

  Roles Investigation, Methodology

  Affiliation State Key Laboratory of Animal Disease Prevention and Control, National African Swine Fever Para-Reference Laboratory, National High-Containment Facilities for Animal Diseases Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, Heilongjiang, China

  ⨯
• Zhanhao Guo,

  Roles Investigation, Methodology

  Affiliation State Key Laboratory of Animal Disease Prevention and Control, National African Swine Fever Para-Reference Laboratory, National High-Containment Facilities for Animal Diseases Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, Heilongjiang, China

  ⨯
• Yuxin Qu,

  Roles Investigation

  Affiliation State Key Laboratory of Animal Disease Prevention and Control, National African Swine Fever Para-Reference Laboratory, National High-Containment Facilities for Animal Diseases Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, Heilongjiang, China

  ⨯
• Xiao Wang,

  Roles Investigation

  Affiliation School of Basic Medical Sciences, Binzhou Medical University, Yantai, Shandong, China

  ⨯
• Hao Deng,

  Roles Investigation

  Affiliation State Key Laboratory of Animal Disease Prevention and Control, National African Swine Fever Para-Reference Laboratory, National High-Containment Facilities for Animal Diseases Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, Heilongjiang, China

  ⨯
• Jingwen Dai,

  Roles Investigation

  Affiliation State Key Laboratory of Animal Disease Prevention and Control, National African Swine Fever Para-Reference Laboratory, National High-Containment Facilities for Animal Diseases Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, Heilongjiang, China

  ⨯
• Lian-Feng Li,

  Roles Investigation

  Affiliation State Key Laboratory of Animal Disease Prevention and Control, National African Swine Fever Para-Reference Laboratory, National High-Containment Facilities for Animal Diseases Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, Heilongjiang, China

  ⨯
• Wen-Rui He,

  Roles Methodology

  Affiliation International Joint Research Center for National Animal Immunology, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, Henan, China

  ⨯
• Haojie Ren,

  Roles Methodology

  Affiliation International Joint Research Center for National Animal Immunology, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, Henan, China

  ⨯
• Zhaobing Gao ,

  Roles Investigation, Methodology, Supervision, Validation, Writing – review & editing

  * E-mail: zbgao@simm.ac.cn (ZG); xiabingqing@simm.ac.cn (BX); lisu@caas.cn (SL); qiuhuaji@caas.cn (H-JQ)

  Affiliation CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

  ⨯
• Bingqing Xia ,

  Roles Data curation, Investigation, Methodology, Supervision, Validation, Writing – review & editing

  * E-mail: zbgao@simm.ac.cn (ZG); xiabingqing@simm.ac.cn (BX); lisu@caas.cn (SL); qiuhuaji@caas.cn (H-JQ)

  Affiliation CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

  ⨯
• Su Li ,

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Supervision, Validation, Writing – review & editing

  * E-mail: zbgao@simm.ac.cn (ZG); xiabingqing@simm.ac.cn (BX); lisu@caas.cn (SL); qiuhuaji@caas.cn (H-JQ)

  Affiliation State Key Laboratory of Animal Disease Prevention and Control, National African Swine Fever Para-Reference Laboratory, National High-Containment Facilities for Animal Diseases Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, Heilongjiang, China

  ⨯
• Hua-Ji Qiu

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Supervision, Validation, Writing – review & editing

  * E-mail: zbgao@simm.ac.cn (ZG); xiabingqing@simm.ac.cn (BX); lisu@caas.cn (SL); qiuhuaji@caas.cn (H-JQ)

  Affiliation State Key Laboratory of Animal Disease Prevention and Control, National African Swine Fever Para-Reference Laboratory, National High-Containment Facilities for Animal Diseases Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, Heilongjiang, China

  https://orcid.org/0000-0001-5791-0812

  ⨯