SAMHD1 depletion restricts SARS-CoV-2 infection by suppressing HNF1-dependent ACE2 expression in lung epithelial cells

Pak-Hin Hinson Cheung; Pearl Chan; Hua Yang; Krisztina Ambrus; Shravya Honne; Baek Kim; Stanley Perlman; Li Wu

doi:10.1371/journal.ppat.1013659

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Open Access

Peer-reviewed

Research Article

SAMHD1 depletion restricts SARS-CoV-2 infection by suppressing HNF1-dependent ACE2 expression in lung epithelial cells

Pak-Hin Hinson Cheung ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

* E-mail: pakhinhinson-cheung@uiowa.edu (PHC); li-wu@uiowa.edu (LW)

Affiliation Department of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
⨯
Pearl Chan,

Roles Methodology, Writing – review & editing

Affiliation Department of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
⨯
Hua Yang,

Roles Methodology, Visualization, Writing – review & editing

Affiliation Department of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
⨯
Krisztina Ambrus,

Roles Data curation, Formal analysis, Investigation

Affiliation Department of Pediatrics, School of Medicine, Emory University, Atlanta, GeorgiaUnited States of America
⨯
Shravya Honne,

Roles Data curation, Formal analysis, Investigation

Affiliation Department of Pediatrics, School of Medicine, Emory University, Atlanta, GeorgiaUnited States of America
⨯
Baek Kim,

Roles Funding acquisition, Methodology, Project administration, Resources, Supervision

Affiliation Department of Pediatrics, School of Medicine, Emory University, Atlanta, GeorgiaUnited States of America
⨯
Stanley Perlman,

Roles Funding acquisition, Resources, Supervision, Writing – review & editing

Affiliation Department of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
⨯
Li Wu

Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: pakhinhinson-cheung@uiowa.edu (PHC); li-wu@uiowa.edu (LW)

Affiliation Department of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America

https://orcid.org/0000-0002-5468-2487

⨯

SAMHD1 depletion restricts SARS-CoV-2 infection by suppressing HNF1-dependent ACE2 expression in lung epithelial cells

Pak-Hin Hinson Cheung,
Pearl Chan,
Hua Yang,
Krisztina Ambrus,
Shravya Honne,
Baek Kim,
Stanley Perlman,
Li Wu

Published: March 19, 2026
https://doi.org/10.1371/journal.ppat.1013659

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