The monoclonal antibody AZD5148 confers broad protection against TcdB-diverse Clostridioides difficile strains in mice

• F. Christopher Peritore-Galve,

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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• Heather K. Kroh,

  Roles Conceptualization, Investigation, Methodology, Visualization, Writing – review & editing

  Affiliation Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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• John A. Shupe,

  Roles Conceptualization, Investigation, Methodology, Visualization

  Affiliation Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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• Alyssa G. Ehni,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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• Rubén Cano Rodríguez,

  Roles Investigation, Methodology

  Affiliation Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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• Shannon L. Kordus,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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• M. Kay Washington,

  Roles Investigation

  Affiliation Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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• Reece J. Knippel,

  Roles Conceptualization, Funding acquisition, Methodology, Writing – review & editing

  Affiliation Early Vaccines and Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, Maryland, United States of America

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• Ann Marie Stanley,

  Roles Conceptualization, Funding acquisition, Methodology, Writing – review & editing

  Affiliation Early Vaccines and Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, Maryland, United States of America

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• Adam Gamson,

  Roles Methodology

  Affiliation Early Vaccines and Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, Maryland, United States of America

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• Christine Tkaczyk,

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Visualization, Writing – review & editing

  Affiliation Early Vaccines and Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, Maryland, United States of America

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• D. Borden Lacy

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: borden.lacy@vanderbilt.edu

  Affiliations Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, Tennessee, United States of America

  https://orcid.org/0000-0003-2273-8121

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