The hyaluronan receptor CD44 drives COVID-19 severity through its regulation of neutrophil migration

• Duncan J. Hart,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Microbiology, Immunology and Cancer Biology, University of Virginia School of Medicine, Charlottesville, Virginia, United States of America

  https://orcid.org/0000-0003-0106-6020

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• Md. Jashim Uddin,

  Roles Conceptualization, Data curation, Investigation, Methodology, Visualization, Writing – review & editing

  Affiliation Department of Microbiology, Immunology and Cancer Biology, University of Virginia School of Medicine, Charlottesville, Virginia, United States of America

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• Rebecca J. Dodd,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Visualization, Writing – review & editing

  Affiliations Lydia Becker Institute of Immunology and Inflammation, School of Biological Sciences, University of Manchester, Manchester Academic Health Sciences Centre, Manchester, United Kingdom, Manchester Cell-Matrix Centre, School of Biological Sciences, Faculty of Biology Medicine and Health, University of Manchester, Manchester Academic Health Sciences Centre, Manchester, United Kingdom

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• Savannah G. Brovero,

  Roles Data curation, Investigation

  Affiliation Department of Microbiology, Immunology and Cancer Biology, University of Virginia School of Medicine, Charlottesville, Virginia, United States of America

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• Claire Fleming,

  Roles Conceptualization, Data curation, Investigation, Methodology, Visualization, Writing – review & editing

  Affiliation Department of Microbiology, Immunology and Cancer Biology, University of Virginia School of Medicine, Charlottesville, Virginia, United States of America

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• Gregory Brett Moreau,

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliations Division of Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, Virginia, United States of America, Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, United States of America

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• Nick R. Natale,

  Roles Conceptualization, Methodology, Visualization, Writing – review & editing

  Affiliation Department of Neuroscience, Center for Brain Immunology and Glia (BIG), University of Virginia, Charlottesville, Virginia, Unites States of America

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• Farha Naz,

  Roles Data curation, Methodology

  Affiliation Division of Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, Virginia, United States of America

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• Barbara J. Mann,

  Roles Conceptualization, Investigation, Methodology, Supervision, Writing – review & editing

  Affiliations Department of Microbiology, Immunology and Cancer Biology, University of Virginia School of Medicine, Charlottesville, Virginia, United States of America, Division of Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, Virginia, United States of America

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• Tara E. Sutherland,

  Roles Conceptualization, Methodology, Validation, Writing – review & editing

  Affiliation Institute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, United Kingdom

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• Judith E. Allen,

  Roles Conceptualization, Funding acquisition, Methodology, Validation, Writing – review & editing

  Affiliations Lydia Becker Institute of Immunology and Inflammation, School of Biological Sciences, University of Manchester, Manchester Academic Health Sciences Centre, Manchester, United Kingdom, Manchester Cell-Matrix Centre, School of Biological Sciences, Faculty of Biology Medicine and Health, University of Manchester, Manchester Academic Health Sciences Centre, Manchester, United Kingdom

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• Anthony J. Day,

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Validation, Visualization, Writing – review & editing

  Affiliations Lydia Becker Institute of Immunology and Inflammation, School of Biological Sciences, University of Manchester, Manchester Academic Health Sciences Centre, Manchester, United Kingdom, Manchester Cell-Matrix Centre, School of Biological Sciences, Faculty of Biology Medicine and Health, University of Manchester, Manchester Academic Health Sciences Centre, Manchester, United Kingdom

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• William A. Petri Jr

  Roles Conceptualization, Funding acquisition, Methodology, Supervision, Validation, Visualization, Writing – review & editing

  * E-mail: wap3g@virginia.edu

  Affiliations Department of Microbiology, Immunology and Cancer Biology, University of Virginia School of Medicine, Charlottesville, Virginia, United States of America, Division of Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, Virginia, United States of America, Department of Pathology, University of Virginia School of Medicine, Charlottesville, Virginia, United States of America

  https://orcid.org/0000-0002-7268-1218

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