A comprehensive PDCoV-host proteome interaction map reveals potential antiviral targets

Wenjun Yan; Kailu Wang; Song Liu; Rongbin Qiu; Qingcheng Yang; Hao Li; Siyu Huang; Chengyao Hou; Qinyuan Chu; Yue Sun; Yizhi Tang; Changwei Lei; Yiming Tian; Hongning Wang; Xin Yang

doi:10.1371/journal.ppat.1013615

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Open Access

Peer-reviewed

Research Article

A comprehensive PDCoV-host proteome interaction map reveals potential antiviral targets

Wenjun Yan ,

Contributed equally to this work with: Wenjun Yan, Kailu Wang, Song Liu, Rongbin Qiu

Roles Resources, Software, Writing – original draft

Affiliation Animal Disease Prevention and Green Development Key Laboratory of Sichuan Province, College of Life Science, Sichuan University, Chengdu, China
⨯
Kailu Wang ,

Contributed equally to this work with: Wenjun Yan, Kailu Wang, Song Liu, Rongbin Qiu

Roles Investigation, Methodology, Resources

Affiliation Animal Disease Prevention and Green Development Key Laboratory of Sichuan Province, College of Life Science, Sichuan University, Chengdu, China
⨯
Song Liu ,

Contributed equally to this work with: Wenjun Yan, Kailu Wang, Song Liu, Rongbin Qiu

Roles Methodology

Affiliation Animal Disease Prevention and Green Development Key Laboratory of Sichuan Province, College of Life Science, Sichuan University, Chengdu, China
⨯
Rongbin Qiu ,

Contributed equally to this work with: Wenjun Yan, Kailu Wang, Song Liu, Rongbin Qiu

Roles Conceptualization, Data curation

Affiliation College of Life Science and Engineering, Southwest University of Science and Technology, Mianyang, China
⨯
Qingcheng Yang,

Roles Formal analysis

Affiliation Animal Disease Prevention and Green Development Key Laboratory of Sichuan Province, College of Life Science, Sichuan University, Chengdu, China
⨯
Hao Li,

Roles Visualization

Affiliation Animal Disease Prevention and Green Development Key Laboratory of Sichuan Province, College of Life Science, Sichuan University, Chengdu, China
⨯
Siyu Huang,

Roles Visualization

Affiliation Animal Disease Prevention and Green Development Key Laboratory of Sichuan Province, College of Life Science, Sichuan University, Chengdu, China
⨯
Chengyao Hou,

Roles Methodology

Affiliation Animal Disease Prevention and Green Development Key Laboratory of Sichuan Province, College of Life Science, Sichuan University, Chengdu, China
⨯
Qinyuan Chu,

Roles Resources, Supervision

Affiliation Animal Disease Prevention and Green Development Key Laboratory of Sichuan Province, College of Life Science, Sichuan University, Chengdu, China
⨯
Yue Sun,

Roles Formal analysis, Methodology

Affiliation Animal Disease Prevention and Green Development Key Laboratory of Sichuan Province, College of Life Science, Sichuan University, Chengdu, China
⨯
Yizhi Tang,

Roles Software

Affiliation Animal Disease Prevention and Green Development Key Laboratory of Sichuan Province, College of Life Science, Sichuan University, Chengdu, China
⨯
Changwei Lei,

Roles Conceptualization, Data curation

Affiliation Animal Disease Prevention and Green Development Key Laboratory of Sichuan Province, College of Life Science, Sichuan University, Chengdu, China
⨯
Yiming Tian,

Roles Methodology, Visualization

Affiliation Guizhou Medical University, Guiyang, China
⨯
Hongning Wang ,

Roles Writing – review & editing

* E-mail: whongning@163.com (HW); yangxin0822@163.com (XY)

Affiliation Animal Disease Prevention and Green Development Key Laboratory of Sichuan Province, College of Life Science, Sichuan University, Chengdu, China
⨯
Xin Yang

Roles Funding acquisition, Writing – review & editing

* E-mail: whongning@163.com (HW); yangxin0822@163.com (XY)

Affiliation Animal Disease Prevention and Green Development Key Laboratory of Sichuan Province, College of Life Science, Sichuan University, Chengdu, China

https://orcid.org/0000-0002-7940-714X

⨯

A comprehensive PDCoV-host proteome interaction map reveals potential antiviral targets

Wenjun Yan,
Kailu Wang,
Song Liu,
Rongbin Qiu,
Qingcheng Yang,
Hao Li,
Siyu Huang,
Chengyao Hou,
Qinyuan Chu,
Yue Sun

Published: October 24, 2025
https://doi.org/10.1371/journal.ppat.1013615

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Host-pathogen interactions
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Viral replication
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Protein interactions
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RNA viruses
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Interaction networks
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Protein expression
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Coronaviruses
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Ubiquitination
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