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Phosphorylation of SNAP-25 at Ser187 is enhanced following its cleavage by Botulinum Neurotoxin Serotype A, promoting the dominant-negative effect of the resulting fragment
- Dilara Koc ,
- Sena Ezgin ,
- Ebru Kavakli,
- Krishna P. Kota,
- Edanur Sen,
- Christopher Mahone,
- Mary Ellen Palko,
- Lisa H. Cazares,
- Tolga Can,
- Lino Tessarollo,
- Sina Bavari,
- Antoine Marion,
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Erkan Kiris
Roles Conceptualization, Funding acquisition, Investigation, Supervision, Writing – original draft, Writing – review & editing
* E-mail: ekiris@metu.edu.tr
Affiliation Department of Biological Sciences, Middle East Technical University, Cankaya, Ankara, Turkey
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https://orcid.org/0000-0003-2095-0460
Phosphorylation of SNAP-25 at Ser187 is enhanced following its cleavage by Botulinum Neurotoxin Serotype A, promoting the dominant-negative effect of the resulting fragment
- Dilara Koc,
- Sena Ezgin,
- Ebru Kavakli,
- Krishna P. Kota,
- Edanur Sen,
- Christopher Mahone,
- Mary Ellen Palko,
- Lisa H. Cazares,
- Tolga Can,
- Lino Tessarollo
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- Published: October 14, 2025
- https://doi.org/10.1371/journal.ppat.1013604