Lactic acid produced by optimal vaginal Lactobacillus spp. potently and specifically inactivates HIV-1 in vitro by targeting the viral RNA genome and reverse transcriptase

• Muriel Aldunate,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Life Sciences Discipline and Disease Elimination Program, Burnet Institute, Melbourne, Victoria, Australia, Department of Microbiology, Monash University, Clayton, Victoria, Australia

  ⨯
• David Tyssen,

  Roles Data curation, Formal analysis, Investigation, Methodology, Supervision, Writing – review & editing

  Affiliation Life Sciences Discipline and Disease Elimination Program, Burnet Institute, Melbourne, Victoria, Australia

  ⨯
• Adam Johnson,

  Roles Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation, Visualization, Writing – review & editing

  Affiliation Life Sciences Discipline and Disease Elimination Program, Burnet Institute, Melbourne, Victoria, Australia

  ⨯
• Catherine F. Latham,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – review & editing

  Affiliation Life Sciences Discipline and Disease Elimination Program, Burnet Institute, Melbourne, Victoria, Australia

  ⨯
• Paula Ellenberg,

  Roles Formal analysis, Investigation, Methodology, Visualization, Writing – review & editing

  Affiliation Life Sciences Discipline and Disease Elimination Program, Burnet Institute, Melbourne, Victoria, Australia

  ⨯
• Nathan Cowieson,

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Australian Synchrotron, Clayton, Victoria, Australia

  ⨯
• Joshua A. Hayward,

  Roles Data curation, Formal analysis, Methodology, Validation, Visualization, Writing – review & editing

  Affiliations Life Sciences Discipline and Disease Elimination Program, Burnet Institute, Melbourne, Victoria, Australia, Department of Microbiology, Monash University, Clayton, Victoria, Australia

  ⨯
• Rob J. Center ,

  Roles Methodology, Resources, Writing – review & editing

  ¶Deceased

  Affiliations Life Sciences Discipline and Disease Elimination Program, Burnet Institute, Melbourne, Victoria, Australia, Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia

  ⨯
• Paul A. Ramsland,

  Roles Conceptualization, Formal analysis, Methodology, Supervision, Writing – review & editing

  Affiliations Life Sciences Discipline and Disease Elimination Program, Burnet Institute, Melbourne, Victoria, Australia, School of Science, RMIT University, Melbourne, Victoria, Australia, Department of Immunology, Monash University, Melbourne, Victoria, Australia, Department of Surgery, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia,

  ⨯
• Anna C. Hearps,

  Roles Formal analysis, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Life Sciences Discipline and Disease Elimination Program, Burnet Institute, Melbourne, Victoria, Australia, Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia, Department of Infectious Diseases, Monash University, Melbourne, Victoria, Australia, Department of Infectious Diseases, University of Melbourne, Melbourne, Victoria, Australia

  ⨯
• Gilda Tachedjian

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: gildat@burnet.edu.au

  Affiliations Life Sciences Discipline and Disease Elimination Program, Burnet Institute, Melbourne, Victoria, Australia, Department of Microbiology, Monash University, Clayton, Victoria, Australia, Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia

  https://orcid.org/0000-0002-7733-7037

  ⨯